BMI, physical activity, and breast cancer subtype in white, black, and Sea Island breast cancer survivors

被引:6
作者
Ford, Marvella E. [1 ,2 ,3 ]
Bauza, Colleen E. [1 ]
Findlay, Victoria J. [4 ,5 ]
Turner, David P. [4 ,5 ]
Abraham, Latecia M. [6 ]
Moore, Leslie A. [7 ]
Magwood, Gayenell [4 ,8 ]
Alberg, Anthony J. [9 ]
Gaymon, Kadeidre [8 ]
Knight, Kendrea D. [1 ]
Hilton, Ebony [10 ]
Malek, Angela M. [1 ]
Kramer, Rita M. [11 ]
Peterson, Lindsay L. [12 ]
Gregoski, Mathew J. [13 ]
Bolick, Susan [14 ]
Hurley, Deborah [14 ]
Mosley, Catishia [14 ]
Hazelton, Tonya R. [8 ]
Burshell, Dana R. [15 ]
Nogueira, Lourdes [5 ]
Mack, Franshawn [16 ]
Brown, Erika T. [17 ]
Salley, Judith D. [16 ]
Whitfield, Keith E. [18 ]
Esnaola, Nestor F. [19 ,20 ,21 ,22 ]
Cunningham, Joan E. [23 ]
机构
[1] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA
[2] Med Univ South Carolina, Hollings Canc Ctr, Populat Sci & Canc Dispar, Charleston, SC 29425 USA
[3] South Carolina State Univ, Canc Dispar Res, Orangeburg, SC 29117 USA
[4] Med Univ South Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA
[5] Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA
[6] Med Univ South Carolina, Dept Lib Sci & Informat, Charleston, SC 29425 USA
[7] Med Univ South Carolina, Coll Med, Charleston, SC 29425 USA
[8] Med Univ South Carolina, Coll Nursing, Charleston, SC 29425 USA
[9] Univ South Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA
[10] Med Univ South Carolina, Dept Anesthesiol & Perioperat Med, Charleston, SC 29425 USA
[11] Med Univ South Carolina, Dept Hematol Oncol, Charleston, SC 29425 USA
[12] Washington Univ St Louis, Dept Med, St Louis, MO USA
[13] Campbell Univ, Dept Arts & Sci, Buies Creek, NC 27506 USA
[14] South Carolina Dept Hlth & Environm, Columbia, SC USA
[15] Med Univ South Carolina, South Carolina Clin & Translat Res Inst, Clin & Translat Sci Award, Charleston, SC 29425 USA
[16] South Carolina State Univ, Dept Biol & Phys Sci, Orangeburg, SC USA
[17] Morehouse Sch Med, Atlanta, GA 30310 USA
[18] Wayne State Univ, Acad Affairs, Detroit, MI USA
[19] Weill Cornell Med Coll, Houston Methodist Acad Inst, Surg, Houston, TX USA
[20] Houston Methodist Hosp, Dept Surg, Surg Oncol & Gastrointestinal Surg, Houston, TX 77030 USA
[21] Houston Methodist Canc Ctr, Community Engagement & Canc Control, Houston, TX USA
[22] Houston Methodist Res Inst, Houston, TX USA
[23] Natl Coalit Independent Scholars, San Antonio, TX USA
来源
CANCER HEALTH EQUITY RESEARCH | 2020年 / 146卷
基金
美国国家卫生研究院;
关键词
DISPARITIES;
D O I
10.1016/bs.acr.2020.01.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Higher BMI, lower rates of physical activity (PA), and hormone receptor-negative breast cancer (BC) subtype are associated with poorer BC treatment outcomes. We evaluated the prevalence of high BMI, low PA level, and BC subtype among survivors with white/European American (EA) and African American (AA) ancestry, as well as a distinct subset of AAs with Sea Island/Gullah ancestry (SI). We used the South Carolina Central Cancer Registry to identify 137 (42 EAs, 66 AAs, and 29 SIs) women diagnosed with BC and who were within 6-21 months of diagnosis. We employed linear and logistic regression to investigate associations between BMI, PA, and age at diagnosis by racial/ethnic group. Most participants (82%) were overweight/obese (P = 0.46). BMI was highest in younger AAs (P = 0.02). CDC PA guidelines (>= 150 min/week) were met by only 28% of participants. The frequency of estrogen receptor (ER)-negative BC subtype was lower in EAs and SIs than in AAs (P < 0.05). This is the first study to identify differences in obesity and PA rates, and BC subtype in EAs, AAs, and SIs. BMI was higher, PA rates were lower, and frequency of ER-negative BC was higher in AAs as compared to EAs and SIs. This study highlights the need to promote lifestyle interventions among BC survivors, with the goal of reducing the likelihood of a BC recurrence. Integrating dietary and PA interventions into ongoing survivorship care is essential. Future research could evaluate potential differential immune responses linked to the frequency of triple negative BC in AAs.
引用
收藏
页码:83 / 102
页数:20
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