Cancer stem cells and radioresistance

被引：228

作者：

Rycaj, Kiera ^{[1
]}

Tang, Dean G. ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol Carcinogenesis, Smithville, TX 78957 USA

[2] Tongji Univ, Sch Med, Shanghai East Hosp, Canc Stem Cell Inst,Ctr Translat Med, Shanghai 200092, Peoples R China

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2014年 / 90卷 / 08期

关键词：

Cancer stem cells; radiation therapy; radiosensitivity; radioresistance; plasticity; microenvironment; hypoxia; PROTEIN-KINASE-C; KAPPA-B; RADIATION-RESISTANCE; GENOMIC INSTABILITY; IONIZING-RADIATION; INITIATING CELLS; GLIOMA-CELLS; SURVIVAL; GLIOBLASTOMA; BRAIN;

D O I：

10.3109/09553002.2014.892227

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose: Radiation therapy has made significant contributions to cancer treatment. However, despite continuous improvements, tumor recurrence and therapy resistance still occur in a high proportion of patients. One underlying reason for this radioresistance might be attributable to the presence of cancer stem cells (CSC). The purpose of this review is to discuss CSC-specific mechanisms that confer radiation resistance. Conclusions: We focus our discussions on breast cancer and glioblastoma multiforme (GBM) and conclude that both CSC-intrinsic and CSC-extrinsic factors as well as adaptive responses in CSC caused by irradiation and microenvironmental changes all make contributions to CSC-mediated radioresistance. Our discussions emphasize CSC as novel therapeutic targets in order to potentiate radiotherapy efficacy.

引用

页码：615 / 621

页数：7

共 68 条

[1]

Abe O, 2005, LANCET, V366, P2087, DOI 10.1016/s0140-6736(05)66544-0

[2] Coactivation of ATM/ERK/NF-κB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes [J].

Ahmed, Kazi Mokim ;

Nantajit, Danupon ;

Fan, Ming ;

Murley, Jeffrey S. ;

Grdina, David J. ;

Li, Jian Jian .

FREE RADICAL BIOLOGY AND MEDICINE, 2009, 46 (11) :1543-1550

[3] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[4] Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor [J].

Bao, Shideng ;

Wu, Qiulian ;

Sathornsumetee, Sith ;

Hao, Yueling ;

Li, Zhizhong ;

Hjelmeland, Anita B. ;

Shi, Oing ;

McLendon, Roger E. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

CANCER RESEARCH, 2006, 66 (16) :7843-7848

[5] Exploring the role of cancer stem cells in radioresistance [J].

Baumann, Michael ;

Krause, Mechthild ;

Hill, Richard .

NATURE REVIEWS CANCER, 2008, 8 (07) :545-554

[6] Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma [J].

Bhat, Krishna P. L. ;

Balasubramaniyan, Veerakumar ;

Vaillant, Brian ;

Ezhilarasan, Ravesanker ;

Hummelink, Karlijn ;

Hollingsworth, Faith ;

Wani, Khalida ;

Heathcock, Lindsey ;

James, Johanna D. ;

Goodman, Lindsey D. ;

Conroy, Siobhan ;

Long, Lihong ;

Lelic, Nina ;

Wang, Suzhen ;

Gumin, Joy ;

Raj, Divya ;

Kodama, Yoshinori ;

Raghunathan, Aditya ;

Olar, Adriana ;

Joshi, Kaushal ;

Pelloski, Christopher E. ;

Heimberger, Amy ;

Kim, Se Hoon ;

Cahill, Daniel P. ;

Rao, Ganesh ;

Den Dunnen, Wilfred F. A. ;

Boddeke, Hendrikus W. G. M. ;

Phillips, Heidi S. ;

Nakano, Ichiro ;

Lang, Frederick F. ;

Colman, Howard ;

Sulman, Erik P. ;

Aldape, Kenneth .

CANCER CELL, 2013, 24 (03) :331-346

[7] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[8] NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance [J].

Cao, Ning ;

Li, Shiyong ;

Wang, Zhaoqing ;

Ahmed, Kazi Mokim ;

Degnan, Michael E. ;

Fan, Ming ;

Dynlacht, Joseph R. ;

Li, Jian Jian .

RADIATION RESEARCH, 2009, 171 (01) :9-21

[9] A restricted cell population propagates glioblastoma growth after chemotherapy [J].

Chen, Jian ;

Li, Yanjiao ;

Yu, Tzong-Shiue ;

McKay, Renee M. ;

Burns, Dennis K. ;

Kernie, Steven G. ;

Parada, Luis F. .

NATURE, 2012, 488 (7412) :522-+

[10] L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1 [J].

Cheng, Lin ;

Wu, Qiulian ;

Huang, Zhi ;

Guryanova, Olga A. ;

Huang, Qian ;

Shou, Weinian ;

Rich, Jeremy N. ;

Bao, Shideng .

EMBO JOURNAL, 2011, 30 (05) :800-813

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