Selective excision of C5 from D-ribose in the gas phase by low-energy electrons (0-1 eV): Implications for the mechanism of DNA damage

被引：96

作者：

Bald, Ilko

Kopyra, Janina

Illenberger, Eugen

机构：

[1] Free Univ Berlin, Inst Chem & Biochem Phys & Theoret Chem, D-14195 Berlin, Germany

[2] Univ Podlasie, Dept Chem, PL-08110 Siedlce, Poland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 29期

关键词：

bioorganic chemistry; dissociative electron attachment; DNA damage; gas-phase reactions; negative ion mass spectrometry;

D O I：

10.1002/anie.200600303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Attachment of low-energy electrons to D-ribose triggers a series of complex decomposition reactions associated with the loss of neutral water molecules as well as the excision of C-containing units leading to the degradation of the cyclic structure of the sugar. This excision of C-containing neutral fragments involves C5 exclusively. The sugar unit is thought to play a key role in the mechanism of DNA damage by low-energy electrons. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4851 / 4855

页数：5

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