Neuronal Aneuploidy in Health and Disease: A Cytomic Approach to Understand the Molecular Individuality of Neurons

被引:33
作者
Arendt, Thomas [1 ]
Mosch, Birgit [1 ]
Morawski, Markus [1 ]
机构
[1] Univ Leipzig, Paul Flechsig Inst Brain Res, Leipzig, Germany
关键词
alu-repeats; Alzheimer's disease; cell cycle; cell death; chromosomal mosaicism; in situ hybridisation; laser capture microdissection; neurodegeneration; slide-based cytometry; MOSAIC VARIEGATED ANEUPLOIDY; IN-SITU HYBRIDIZATION; COMPARATIVE GENOMIC HYBRIDIZATION; SEX-CHROMOSOME ANOMALIES; NEURAL PROGENITOR CELLS; CLONALLY RELATED CELLS; HUMAN BRAIN-TUMORS; BETA-PROTEIN GENE; ALZHEIMERS-DISEASE; CEREBRAL-CORTEX;
D O I
10.3390/ijms10041609
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Structural variation in the human genome is likely to be an important mechanism for neuronal diversity and brain disease. A combination of multiple different forms of aneuploid cells due to loss or gain of whole chromosomes giving rise to cellular diversity at the genomic level have been described in neurons of the normal and diseased adult human brain. Here, we describe recent advances in molecular neuropathology based on the combination of slide-based cytometry with molecular biological techniques that will contribute to the understanding of genetic neuronal heterogeneity in the CNS and its potential impact on Alzheimer's disease and age-related disorders.
引用
收藏
页码:1609 / 1627
页数:19
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