Role of tRNA modifications in human diseases

被引：303
作者：
Gabriel Torres, Adrian [1 ]
Batlle, Eduard [1 ,2 ]
Ribas de Pouplana, Lluis [1 ,2 ]
机构：
[1] Inst Biomed Res, Catalunya 08028, Spain
[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Catalunya, Spain
来源：
TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 06期
关键词：
tRNA; tRNA modifications; human disease; neurological disorders; cancer; COMPARATIVE GENOMIC HYBRIDIZATION; ANTICODON WOBBLE NUCLEOTIDE; BREAST-CANCER PATIENTS; ADENOSINE-DEAMINASE; MENTAL-RETARDATION; INSULIN-SECRETION; SPLICING MUTATION; EARLY-ONSET; MISU NSUN2; GENE;
D O I：
10.1016/j.molmed.2014.01.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates that tRNA modifications and the enzymes catalyzing such modifications may play important roles in complex human pathologies. Here, we have compiled current knowledge that directly link tRNA modifications to human diseases such as cancer, type 2 diabetes (T2D), neurological disorders, and mitochondrial-linked disorders. The molecular mechanisms behind these connections remain, for the most part, unknown. As we progress towards the understanding of the roles played by hypomodified tRNAs in human disease, novel areas of therapeutic intervention may be discovered.
引用
收藏
页码：306 / 314
页数：9
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