Risk reducing mastectomy: outcomes in 10 European centres

被引：62

作者：

Evans, D. G. R. ^{[1
,2
,3
,4
]}

Baildam, A. D. ^{[5
,6
]}

Anderson, E. ^{[7
]}

Brain, A. ^{[5
,6
]}

Shenton, A. ^{[1
,2
,3
]}

Vasen, H. F. A. ^{[8
]}

Eccles, D. ^{[9
]}

Lucassen, A. ^{[9
]}

Pichert, G. ^{[10
]}

Hamed, H. ^{[10
]}

Moller, P. ^{[11
]}

Maehle, L. ^{[11
]}

Morrison, P. J. ^{[12
]}

Stoppat-Lyonnet, D. ^{[13
]}

Gregory, H. ^{[14
]}

Smyth, E. ^{[14
]}

Niederacher, D. ^{[15
]}

Nestle-Kraemling, C. ^{[15
]}

Campbell, J. ^{[7
]}

Hopwood, P. ^{[16
]}

Lalloo, F. ^{[1
,2
,3
]}

Howell, A. ^{[4
]}

机构：

[1] St Marys Hosp, Cent Manchester & Manchester Childrens Univ Hosp, Manchester M13 0JH, Lancs, England

[2] Univ Manchester, Med Genet Res Grp, Manchester, Lancs, England

[3] Univ Manchester, Reg Genet Serv, Manchester, Lancs, England

[4] Wythenshawe Hosp, Univ S Manchester Hosp, Genesis Prevent Ctr, Manchester M23 9LT, Lancs, England

[5] Wythenshawe Hosp, Dept Breast, Manchester M23 9LT, Lancs, England

[6] Wythenshawe Hosp, Dept Plast Surg, Manchester M23 9LT, Lancs, England

[7] SE Scotland Breast Screening Programme, Edinburgh EH11 2JL, Midlothian, Scotland

[8] Fdn Detect Hereditary Tumours, Leiden, Netherlands

[9] CRC, Genet Epidemiol Res Grp, Wessex Reg Genet Serv, Southampton, Hants, England

[10] Guys Hosp, Div Med & Mol Genet & Surg, London SE1 9RT, England

[11] Univ Oslo, Natl Hosp, Dept Med Genet, Sect Inherited Canc, Oslo, Norway

[12] Belfast HSC Trust, Dept Med Genet, Belfast, Antrim, North Ireland

[13] Inst Curie, Unite Genet Oncol, Paris, France

[14] Univ Aberdeen, Dept Med Genet & Surg, Aberdeen, Scotland

[15] Univ Dusseldorf, Univ Med Clin Dusseldorf, Dept Obstet & Gynecol, Dusseldorf, Germany

[16] Christie NHS Trust, Manchester, Lancs, England

来源：

JOURNAL OF MEDICAL GENETICS | 2009年 / 46卷 / 04期

关键词：

CONTRALATERAL PROPHYLACTIC MASTECTOMY; BRCA2 MUTATION CARRIERS; BREAST-CANCER RISK; HIGH FAMILIAL RISK; OVARIAN-CANCER; WOMEN; HISTORY; SURVEILLANCE; MAMMOGRAPHY; EFFICACY;

D O I：

10.1136/jmg.2008.062232

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Increasingly women at high risk of breast cancer are opting for risk reducing surgery. The aim of this study was to assess the effectiveness of this approach in women at high risk in both carriers and non-carriers of BRCA1/2. Methods: Data from 10 European centres that offer a genetic counselling and screening service to women at risk were obtained prospectively from 1995. Breast cancer risks were estimated from life tables and a control group of women at risk who did not undergo surgery. Results: The combined centres have data on 550 women who have undergone risk reducing mastectomy with greater than 3334 women years of follow-up. Operations were carried out on women with lifetime risks of 25-80%, with an average expected incidence rate of 1% per year. No breast cancers have occurred in this cohort in the "at risk'' unaffected breast, whereas >34 would have been expected. A high rate (2-3.6%) of occult disease was identified in the at risk breast at the time of surgery. Interpretation: We conclude that risk reducing surgery is highly effective.

引用

页码：254 / 258

页数：5

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