Targeting neuroplasticity in patients with neurodegenerative diseases using brain stimulation techniques

被引：28

作者：

Yuan, Ti-Fei ^{[1
,2
]}

Li, Wei-Guang ^{[3
,4
]}

Zhang, Chencheng ^{[5
]}

Wei, Hongjiang ^{[6
]}

Sun, Suya ^{[7
,8
]}

Xu, Nan-Jie ^{[3
,4
]}

Liu, Jun ^{[7
,8
]}

Xu, Tian-Le ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 200030, Peoples R China

[2] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China

[3] Shanghai Jiao Tong Univ, Ctr Brain Sci, Shanghai Childrens Med Ctr, Sch Med, Shanghai 200025, Peoples R China

[4] Shanghai Jiao Tong Univ, Ctr Brain Sci, Dept Anat & Physiol, Sch Med, Shanghai 200025, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Funct Neurosurg, Shanghai 200025, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Biomed Engn, Inst Med Imaging Technol, Shanghai 200030, Peoples R China

[7] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai 200025, Peoples R China

[8] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Sch Med, Shanghai 200025, Peoples R China

来源：

TRANSLATIONAL NEURODEGENERATION | 2020年 / 9卷 / 01期

关键词：

Alzheimer's disease; Parkinson's disease; Synapse; Neurotransmitter; Synaptic plasticity; Brain stimulation; Deep brain stimulation; Transcranial magnetic stimulation; TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX PLASTICITY; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; CORTICAL PLASTICITY; SUBTHALAMIC NUCLEUS; COGNITIVE IMPAIRMENT; EXCITABILITY; MECHANISMS;

D O I：

10.1186/s40035-020-00224-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deficits in synaptic transmission and plasticity are thought to contribute to the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD). Several brain stimulation techniques are currently available to assess or modulate human neuroplasticity, which could offer clinically useful interventions as well as quantitative diagnostic and prognostic biomarkers. In this review, we discuss several brain stimulation techniques, with a special emphasis on transcranial magnetic stimulation and deep brain stimulation (DBS), and review the results of clinical studies that applied these techniques to examine or modulate impaired neuroplasticity at the local and network levels in patients with AD or PD. The impaired neuroplasticity can be detected in patients at the earlier and later stages of both neurodegenerative diseases. However, current brain stimulation techniques, with a notable exception of DBS for PD treatment, cannot serve as adequate clinical tools to assist in the diagnosis, treatment, or prognosis of individual patients with AD or PD. Targeting the impaired neuroplasticity with improved brain stimulation techniques could offer a powerful novel approach for the treatment of AD and PD.

引用

页数：10

共 90 条

[1] Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer's dementia [J].