Stressing on the nucleolus in cardiovascular disease

被引：34
作者：
Hariharan, Nirmala [1 ]
Sussman, Mark A. [1 ]
机构：
[1] San Diego State Univ, Dept Biol, Inst Heart, San Diego, CA 92182 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2014年 / 1842卷 / 06期
关键词：
Nucleolus; Heart; Cardiovascular; Disease; CELL-CYCLE ARREST; NF-KAPPA-B; STEM-CELLS; ARTERIAL-HYPERTENSION; PROTEIN NUCLEOSTEMIN; ENDOTHELIAL-CELLS; HEART-DISEASE; CANCER-CELLS; NUCLEOPHOSMIN; FIBRILLARIN;
D O I：
10.1016/j.bbadis.2013.09.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：798 / 801
页数：4
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