Iron(III) Catecholates for Cellular Imaging and Photocytotoxicity in Red Light

被引：32

作者：

Basu, Uttara ^{[1
]}

Pant, Ila ^{[2
]}

Khan, Imran ^{[2
]}

Hussain, Akhtar ^{[1
]}

Kondaiah, Paturu ^{[2
]}

Chakravarty, Akhil R. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Mol Reprod Dev & Genet, Bangalore 560012, Karnataka, India

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 09期

关键词：

apoptosis; bioinorganic chemistry; DNA cleavage; iron; photocytotoxicity; NEAR-IR LIGHT; DNA CLEAVAGE; COMPLEXES; LIGANDS; METAL; DIOXYGENASES; BLEOMYCIN; MECHANISM; THERAPY; BINDING;

D O I：

10.1002/asia.201402207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iron(III) complexes [ Fe(L)(L') (NO3)]-in which L is phenyl-N, N-bis[(pyridin-2-yl) methyl]methanamine (1), (anthracen-9-yl)N, N-bis[(pyridin-2-yl) methyl] methanamine (2), (pyreny-1-yl)-N, N-bis[(pyridin- 2-yl) methyl] methanamine (3-5), and L' is catecholate (1-3), 4-tert-butyl catecholate (4), and 4-(2-aminoethyl)benzene- 1,2-diolate (5)-were synthesized and their photocytotoxic proper-ties examined. The five electron-paramagnetic complexes displayed a FeIII/ Fe-II redox couple near similar to 0.4 V versus a saturated calomel electrode (SCE) in DMF/0.1m tetrabutylammonium perchlorate (TBAP). They showed unpre-cedented photocytotoxicity in red light (600-720 nm) to give IC50-15 mm in various cell lines by means of apoptosis to generate reactive oxygen species. They were ingested in the nucleus of HeLa and HaCaT cells in 4 h, thereby interacting favorably with calf thymus (ct)-DNA and photocleaving pUC19 DNA in red light of 785 nm to form hydroxyl radicals.

引用

页码：2494 / 2504

页数：11

共 52 条

[1] Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles [J].