The Pathogenesis of Focal Segmental Glomerulosclerosis

被引：89

作者：

Jefferson, J. Ashley ^{[1
]}

Shanland, Stuart J. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Div Nephrol, Seattle, WA 98195 USA

来源：

ADVANCES IN CHRONIC KIDNEY DISEASE | 2014年 / 21卷 / 05期

关键词：

Focal segmental glomerulosclerosis; Podocyte; Parietal epithelial cell; Proteinuria; Glomerular disease; PARIETAL EPITHELIAL-CELLS; DIABETIC-NEPHROPATHY; KIDNEY-DISEASE; PODOCYTE REGENERATION; GLOMERULAR SCLEROSIS; UROKINASE RECEPTOR; NEPHROTIC SYNDROME; INJURY; PROTEINURIA; NUMBER;

D O I：

10.1053/j.ackd.2014.05.009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury on kidney biopsy that can arise from a diverse range of causes and mechanisms. Although primary and secondary forms are described based on the underlying cause, there are many common factors that underlie the development of this segmental injury. In this review, we will describe the currently accepted model for the pathogenesis of classic FSGS and review the data supporting this model. Although the podocyte is considered the major target of injury in FSGS, we will also highlight the contributions of other resident glomerular cells in the development of FSGS. (C) 2014 by the National Kidney Foundation, Inc. All rights reserved.

引用

页码：408 / 416

页数：9

共 59 条

[11] Activation of a local tissue angiotensin system in podocytes by mechanical strain [J].

Durvasula, RV ;

Petermann, AT ;

Hiromura, K ;

Blonski, M ;

Pippin, J ;

Mundel, P ;

Pichler, R ;

Griffin, S ;

Couser, WG ;

Shankland, SJ .

KIDNEY INTERNATIONAL, 2004, 65 (01) :30-39

[12] VEGF inhibition and renal thrombotic microangiopathy [J].

Eremina, Vera ;

Jefferson, J. Ashley ;

Kowalewska, Jolanta ;

Hochster, Howard ;

Haas, Mark ;

Weisstuch, Joseph ;

Richardson, Catherine ;

Kopp, Jeffrey B. ;

Kabir, M. Golam ;

Backx, Peter H. ;

Gerber, Hans-Peter ;

Ferrara, Napoleone ;

Barisoni, Laura ;

Alpers, Charles E. ;

Quaggin, Susan E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (11) :1129-1136

[13] Parietal Epithelial Cell Activation Marker in Early Recurrence of FSGS in the Transplant [J].

Fatima, Huma ;

Moeller, Marcus J. ;

Smeets, Bart ;

Yang, Hai-Chun ;

D'Agati, Vivette D. ;

Alpers, Charles E. ;

Fogo, Agnes B. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 7 (11) :1852-1858

[14] Growth-Dependent Podocyte Failure Causes Glomerulosclerosis [J].

Fukuda, Akihiro ;

Chowdhury, Mahboob A. ;

Venkatareddy, Madhusudan P. ;

Wang, Su Q. ;

Nishizono, Ryuzoh ;

Suzuki, Tsukasa ;

Wickman, Larysa T. ;

Wiggins, Jocelyn E. ;

Muchayi, Timothy ;

Fingar, Diane ;

Shedden, Kerby A. ;

Inoki, Ken ;

Wiggins, Roger C. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (08) :1351-1363

[15] Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease [J].

Fukuda, Akihiro ;

Wickman, Larysa T. ;

Venkatareddy, Madhusudan P. ;

Sato, Yuji ;

Chowdhury, Mahboob A. ;

Wang, Su Q. ;

Shedden, Kerby A. ;

Dysko, Robert C. ;

Wiggins, Jocelyn E. ;

Wiggins, Roger C. .

KIDNEY INTERNATIONAL, 2012, 81 (01) :40-55

[16] ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling [J].

Gee, Heon Yung ;

Saisawat, Pawaree ;

Ashraf, Shazia ;

Hurd, Toby W. ;

Vega-Warner, Virginia ;

Fang, Humphrey ;

Beck, Bodo B. ;

Gribouval, Olivier ;

Zhou, Weibin ;

Diaz, Katrina A. ;

Natarajan, Sivakumar ;

Wiggins, Roger C. ;

Lovric, Svjetlana ;

Chernin, Gil ;

Schoeb, Dominik S. ;

Ovunc, Bugsu ;

Frishberg, Yaacov ;

Soliman, Neveen A. ;

Fathy, Hanan M. ;

Goebel, Heike ;

Hoefele, Julia ;

Weber, Lutz T. ;

Innis, Jeffrey W. ;

Faul, Christian ;

Han, Zhe ;

Washburn, Joseph ;

Antignac, Corinne ;

Levy, Shawn ;

Otto, Edgar A. ;

Hildebrandt, Friedhelm .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (08) :3243-3253

[17] Podocyte Regeneration Who Can Become a Podocyte? [J].

Grahammer, Florian ;

Wanner, Nicola ;

Huber, Tobias B. .

AMERICAN JOURNAL OF PATHOLOGY, 2013, 183 (02) :333-335

[18] Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags [J].

Hackl, Matthias J. ;

Burford, James L. ;

Villanueva, Katie ;

Lam, Lisa ;

Susztak, Katalin ;

Schermer, Bernhard ;

Benzing, Thomas ;

Peti-Peterdi, Janos .

NATURE MEDICINE, 2013, 19 (12) :1661-1666

[19] Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats [J].

Hoffmann, S ;

Podlich, D ;

Hähnel, B ;

Kriz, W ;

Gretz, N .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (06) :1475-1487

[20] Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis [J].

Isermann, Berend ;

Vinnikov, Ilya A. ;

Madhusudhan, Thati ;

Herzog, Stefanie ;

Kashif, Muhammed ;

Blautzik, Janusch ;

Corat, Marcus A. F. ;

Zeier, Martin ;

Blessing, Erwin ;

Oh, Jun ;

Gerlitz, Bruce ;

Berg, David T. ;

Grinnell, Brian W. ;

Chavakis, Triantafyllos ;

Esmon, Charles T. ;

Weiler, Hartmut ;

Bierhaus, Angelika ;

Nawroth, Peter P. .

NATURE MEDICINE, 2007, 13 (11) :1349-1358

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