The Pathogenesis of Focal Segmental Glomerulosclerosis

被引：89

作者：

Jefferson, J. Ashley ^{[1
]}

Shanland, Stuart J. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Div Nephrol, Seattle, WA 98195 USA

来源：

ADVANCES IN CHRONIC KIDNEY DISEASE | 2014年 / 21卷 / 05期

关键词：

Focal segmental glomerulosclerosis; Podocyte; Parietal epithelial cell; Proteinuria; Glomerular disease; PARIETAL EPITHELIAL-CELLS; DIABETIC-NEPHROPATHY; KIDNEY-DISEASE; PODOCYTE REGENERATION; GLOMERULAR SCLEROSIS; UROKINASE RECEPTOR; NEPHROTIC SYNDROME; INJURY; PROTEINURIA; NUMBER;

D O I：

10.1053/j.ackd.2014.05.009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury on kidney biopsy that can arise from a diverse range of causes and mechanisms. Although primary and secondary forms are described based on the underlying cause, there are many common factors that underlie the development of this segmental injury. In this review, we will describe the currently accepted model for the pathogenesis of classic FSGS and review the data supporting this model. Although the podocyte is considered the major target of injury in FSGS, we will also highlight the contributions of other resident glomerular cells in the development of FSGS. (C) 2014 by the National Kidney Foundation, Inc. All rights reserved.

引用

页码：408 / 416

页数：9

共 59 条

[1] Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis [J].

Akilesh, Shreeram ;

Suleiman, Hani ;

Yu, Haiyang ;

Stander, M. Christine ;

Lavin, Peter ;

Gbadegesin, Rasheed ;

Antignac, Corinne ;

Pollak, Martin ;

Kopp, Jeffrey B. ;

Winn, Michelle P. ;

Shaw, Andrey S. .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) :4127-4137

[2] Recruitment of Podocytes from Glomerular Parietal Epithelial Cells [J].

Appel, Daniel ;

Kershaw, David B. ;

Smeets, Bart ;

Yuan, Gang ;

Fuss, Astrid ;

Frye, Bjoern ;

Elger, Marlies ;

Kriz, Wilhelm ;

Floege, Juergen ;

Moeller, Marcus J. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (02) :333-343

[3] Inhibiting Angiotensin-Converting Enzyme Promotes Renal Repair by Limiting Progenitor Cell Proliferation and Restoring the Glomerular Architecture [J].

Benigni, Ariela ;

Morigi, Marina ;

Rizzo, Paola ;

Gagliardini, Elena ;

Rota, Cinzia ;

Abbate, Mauro ;

Ghezzi, Serena ;

Remuzzi, Andrea ;

Remuzzi, Giuseppe .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 179 (02) :628-638

[4] The Regenerative Potential of Parietal Epithelial Cells in Adult Mice [J].

Berger, Katja ;

Schulte, Kevin ;

Boor, Peter ;

Kuppe, Christoph ;

van Kuppevelt, Toin H. ;

Floege, Juergen ;

Smeets, Bart ;

Moeller, Marcus J. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 25 (04) :693-705

[5] Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc [J].

Bock, Fabian ;

Shahzad, Khurrum ;

Wang, Hongjie ;

Stoyanov, Stoyan ;

Wolter, Juliane ;

Dong, Wei ;

Pelicci, Pier Giuseppe ;

Kashif, Muhammed ;

Ranjan, Satish ;

Schmidt, Simone ;

Ritzel, Robert ;

Schwenger, Vedat ;

Reymann, Klaus G. ;

Esmon, Charles T. ;

Madhusudhan, Thati ;

Nawroth, Peter P. ;

Isermann, Berend .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (02) :648-653

[6] NEPHRON ADAPTATION TO RENAL INJURY OR ABLATION [J].

BRENNER, BM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (03) :F324-F337

[7] Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2 [J].

Chang, Alice M. ;

Ohse, Takamoto ;

Krofft, Ron D. ;

Wu, Jimmy S. ;

Eddy, Allison A. ;

Pippin, Jeffrey W. ;

Shankland, Stuart J. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 (04) :1330-1343

[8] Pathologic classification of focal segmental glomerulosclerosis: A working proposal [J].

D'Agati, VD ;

Fogo, AB ;

Bruijn, JA ;

Jennette, JC .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2004, 43 (02) :368-382

[9] α-actinin-4 is required for normal podocyte adhesion [J].

Dandapani, Savita V. ;

Sugimoto, Hikaru ;

Matthews, Benjamin D. ;

Kolb, Robert J. ;

Sinha, Sumita ;

Gerszten, Robert E. ;

Zhou, Jing ;

Ingber, Donald E. ;

Kalluri, Raghu ;

Pollak, Martin R. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (01) :467-477

[10] The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis [J].

Dijkman, H ;

Smeets, B ;

van der Laak, J ;

Steenbergen, E ;

Wetzels, J .

KIDNEY INTERNATIONAL, 2005, 68 (04) :1562-1572

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