Type 2 diabetes mellitus-related genetic polymorphisms in microRNAs and microRNA target sites

被引：38

作者：

Gong, Weijing ^{[1
,2
]}

Xiao, Di ^{[1
,2
]}

Ming, Guangfeng ^{[1
,2
]}

Yin, Jiye ^{[1
,2
]}

Zhou, Honghao ^{[1
,2
]}

Liu, Zhaoqian ^{[1
,2
]}

机构：

[1] Cent South Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China

来源：

JOURNAL OF DIABETES | 2014年 / 6卷 / 04期

基金：

中国国家自然科学基金;

关键词：

genetic polymorphism; microRNA target sites; microRNA; type 2 diabetes mellitus; ACAA-INSERTION/DELETION POLYMORPHISM; SINGLE-NUCLEOTIDE POLYMORPHISMS; GENOME-WIDE ASSOCIATION; INSULIN-RESISTANCE; MESSENGER-RNAS; PEPTIDE YY; LIPOPROTEIN-LIPASE; COMMON VARIANTS; INCREASED RISK; BINDING-SITES;

D O I：

10.1111/1753-0407.12143

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) are important endogenous regulators in eukaryotic gene expression and a broad range of biological processes. MiRNA-related genetic variations have been proved to be associated with human diseases, such as type 2 diabetes mellitus (T2DM). Polymorphisms in miRNA genes (primary miRNAs, precursor miRNAs, mature miRNAs, and miRNA regulatory regions) may be involved in the development of T2DM by changing the expression and structure of miRNAs and target gene expression. Genetic polymorphisms of the 3'-untranslated region (UTR) in miRNA target genes may destroy putative miRNA binding sites or create new miRNA binding sites, which affects the binding of UTRs with miRNAs, finally resulting in susceptibility to and development of T2DM. Therefore, focusing on studies into genetic polymorphisms in miRNAs or miRNA binding sites will help our understanding of the pathophysiology of T2DM development and lead to better health management. Herein, we review the association of genetic polymorphisms in miRNA and miRNA targets genes with T2DM development.

引用

页码：279 / 289

页数：11

共 91 条

[1] Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease [J].

Alisi, Anna ;

Da Sacco, Letizia ;

Bruscalupi, Giovannella ;

Piemonte, Fiorella ;

Panera, Nadia ;

De Vito, Rita ;

Leoni, Silvia ;

Bottazzo, Gian Franco ;

Masotti, Andrea ;

Nobili, Valerio .

LABORATORY INVESTIGATION, 2011, 91 (02) :283-293

[2] LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition [J].

Aulchenko, Yurii S. ;

Pullen, Jan ;

Kloosterman, Wigard P. ;

Yazdanpanah, Mojgan ;

Hofman, Albert ;

Vaessen, Norbert ;

Snijders, Pieter J. L. M. ;

Zubakov, Dmitry ;

Mackay, Ian ;

Olavesen, Mark ;

Sidhu, Balbinder ;

Smith, Vicki E. ;

Carey, Alisoun ;

Berezikov, Eugene ;

Uitterlinden, Andre G. ;

Plasterk, Ronald H. A. ;

Oostra, Ben A. ;

van Duijn, Cornelia M. .

DIABETES, 2007, 56 (12) :3020-3026

[3] Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes [J].

Balasubramanyam, M. ;

Aravind, S. ;

Gokulakrishnan, K. ;

Prabu, P. ;

Sathishkumar, C. ;

Ranjani, H. ;

Mohan, V. .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2011, 351 (1-2) :197-205

[4] MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cell lines [J].

Baroukh, Nadine ;

Ravier, Magalie A. ;

Loder, Merewyn K. ;

Hill, Elaine V. ;

Bounacer, Ali ;

Scharfmann, Raphael ;

Rutter, Guy A. ;

Van Obberghen, Emmanuel .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (27) :19575-19588

[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6] The gut hormone peptide YY regulates appetite [J].

Batterham, RL ;

Bloom, SR .

MELANOCORTIN SYSTEM, 2003, 994 :162-168

[7] Low serum PYY is linked to insulin resistance in first-degree relatives of subjects with type 2 diabetes [J].

Boey, Dana ;

Heilbronn, Leonie ;

Sainsbury, Amanda ;

Laybutt, Ross ;

Kriketos, Adamandia ;

Herzog, Herbert ;

Campbell, Lesley V. .

NEUROPEPTIDES, 2006, 40 (05) :317-324

[8] Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets [J].

Bravo-Egana, Valia ;

Rosero, Samuel ;

Klein, Dagmar ;

Jiang, Zhijie ;

Vargas, Nancy ;

Tsinoremas, Nicholas ;

Doni, Marco ;

Podetta, Michele ;

Ricordi, Camillo ;

Molano, R. Damaris ;

Pileggi, Antonello ;

Pastori, Ricardo L. .

JOURNAL OF TRANSPLANTATION, 2012, 2012

[9] Genome-wide scan revealed genetic loci for energy metabolism in Hispanic children and adolescents [J].

Cai, G. ;

Cole, S. A. ;

Butte, N. F. ;

Voruganti, V. S. ;

Comuzzie, A. G. .

INTERNATIONAL JOURNAL OF OBESITY, 2008, 32 (04) :579-585

[10] Replicating genotype-phenotype associations [J].

Chanock, Stephen J. ;

Manolio, Teri ;

Boehnke, Michael ;

Boerwinkle, Eric ;

Hunter, David J. ;

Thomas, Gilles ;

Hirschhorn, Joel N. ;

Abecasis, Goncalo ;

Altshuler, David ;

Bailey-Wilson, Joan E. ;

Brooks, Lisa D. ;

Cardon, Lon R. ;

Daly, Mark ;

Donnelly, Peter ;

Fraumeni, Joseph F., Jr. ;

Freimer, Nelson B. ;

Gerhard, Daniela S. ;

Gunter, Chris ;

Guttmacher, Alan E. ;

Guyer, Mark S. ;

Harris, Emily L. ;

Hoh, Josephine ;

Hoover, Robert ;

Kong, C. Augustine ;

Merikangas, Kathleen R. ;

Morton, Cynthia C. ;

Palmer, Lyle J. ;

Phimister, Elizabeth G. ;

Rice, John P. ;

Roberts, Jerry ;

Rotimi, Charles ;

Tucker, Margaret A. ;

Vogan, Kyle J. ;

Wacholder, Sholom ;

Wijsman, Ellen M. ;

Winn, Deborah M. ;

Collins, Francis S. .

NATURE, 2007, 447 (7145) :655-660

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