The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?

被引：76

作者：

Trapp, Stefan ^{[1
]}

Richards, James E. ^{[1
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 06期

基金：

英国医学研究理事会;

关键词：

CENTRAL-NERVOUS-SYSTEM; FOOD-INTAKE; RAT-BRAIN; LITHIUM-CHLORIDE; RECEPTOR STIMULATION; INSULIN-SECRETION; NUCLEUS-ACCUMBENS; VISCERAL ILLNESS; GLP-1; RECEPTORS; SOLITARY TRACT;

D O I：

10.1016/j.coph.2013.09.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glucagon-like peptide-1 (GLP-1) is both a peripherally expressed incretin and a centrally active neuropeptide. Brain derived GLP-1, produced in preproglucagon (PPG) neurons located in the nucleus of the solitary tract (NTS) and projecting to numerous brain regions, is ideally placed to activate central GLP-1 receptors in a range of autonomic control areas. In vivo analysis of central GLP-1 using GLP-1 receptor antagonists has demonstrated the control of a range of feeding responses mediated by GLP-1 receptor activation. Recent advances enabling identification and targeting of the neurons in the NTS has specifically implicated PPG neurons at the core of GLP-1 dependent central and peripheral control for short-term and long-term energy balance.

引用

页码：964 / 969

页数：6

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