The 3-dimensional cellular automata for HIV infection

被引：9
作者：
Mo, Youbin
Ren, Bin
Yang, Wencao
Shuai, Jianwei [1 ]
机构：
[1] Xiamen Univ, Dept Phys, Xiamen 361005, Fujian, Peoples R China
来源：
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS | 2014年 / 399卷
关键词：
AIDS; HIV; 3-D cellular automata; RETROVIRUSES; DYNAMICS; MODEL; RISK;
D O I：
10.1016/j.physa.2013.12.018
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
The HIV infection dynamics is discussed in detail with a 3-dimensional cellular automata model in this paper. The model can reproduce the three-phase development, i.e., the acute period, the asymptotic period and the AIDS period, observed in the HIV-infected patients in a clinic. We show that the 3D HIV model performs a better robustness on the model parameters than the 2D cellular automata. Furthermore, we reveal that the occurrence of a perpetual source to successively generate infectious waves to spread to the whole system drives the model from the asymptotic state to the AIDS state. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：31 / 39
页数：9
相关论文
共 20 条
[11]   ANTIGENIC DIVERSITY THRESHOLDS AND THE DEVELOPMENT OF AIDS [J].
NOWAK, MA ;
ANDERSON, RM ;
MCLEAN, AR ;
WOLFS, TFW ;
GOUDSMIT, J ;
MAY, RM .
SCIENCE, 1991, 254 (5034) :963-969
[12]  
PANTALEO G, 1993, NEW ENGL J MED, V328, P327, DOI 10.1056/NEJM199302043280508
[13]   Stochastic cellular automata model and Monte Carlo simulations of CD4+ T cell dynamics with a proposed alternative leukapheresis treatment for HIV/AIDS [J].
Precharattana, Monamorn ;
Nokkeaw, Arthorn ;
Triampo, Wannapong ;
Triampo, Darapond ;
Lenbury, Yongwimon .
COMPUTERS IN BIOLOGY AND MEDICINE, 2011, 41 (07) :546-558
[14]   A viral load-based cellular automata approach to modeling HIV dynamics and drug treatment [J].
Shi, Veronica ;
Tridane, Abdessamad ;
Kuang, Yang .
JOURNAL OF THEORETICAL BIOLOGY, 2008, 253 (01) :24-35
[15]  
Sloot P, 2002, LECT NOTES COMPUT SC, V2493, P282
[16]   On cell resistance and immune response time lag in a model for the HIV infection [J].
Solovey, G ;
Peruani, F ;
Dawson, SP ;
dos Santos, RMZ .
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 2004, 343 :543-556
[17]  
Strain M.C., 2002, PHYS REV LETT, V89, P1
[18]   Physical theory of the competition that allows HIV to escape from the immune system [J].
Wang, Guanyu ;
Deem, Michael W. .
PHYSICAL REVIEW LETTERS, 2006, 97 (18)
[19]   A probability cellular automaton model for hepatitis B viral infections [J].
Xiao, X ;
Shao, SH ;
Chou, KC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 342 (02) :605-610
[20]  
Zorzenon dos Santos R.M., 2001, PHYS REV LETT, V87
12