Simulation of bone remodeling around a femoral prosthesis using a model that accounts for biological and mechanical interactions

The present study focuses on a model for three-dimensional bone remodeling of the human femur that considers cellular dynamics to determine the volume fraction of new bone. The model considers the interaction among responsive osteoblasts, active osteoblasts, and osteoclasts, as well as signaling molecules and parathyroid hormone (PTH). The stimulus of the model has a systemic origin due to the PTH effect, and a local origin due to the action of cytokines, growth factors, and mechanical stimuli near the site of the bone cells. The present work considers that the mechanical stimulus that activates cellular activity is obtained from stresses acting on the bone tissue and the number of daily loading cycles. In addition to simulating the bone modeling process in an intact femur, the numerical model is used to simulate bone adaptation in relation to the stress shielding phenomenon after the implantation of a femoral prosthesis. The results showed that the simulations provide a distribution of bone density that is similar to a radiograph and, in addition, allows the visualization of osteoblast and osteoclast dynamics in bone adaptation response after prosthesis implantation. (C) 2020 IPEM. Published by Elsevier Ltd. All rights reserved.