Polymer-Mesoporous Silica Materials Templated with an Oppositely Charged Surfactant/Polymer System for Drug Delivery

被引：46

作者：

Lin, Huiming ^{[1
]}

Zhu, Guangshan ^{[1
]}

Xing, Jiaojiao ^{[1
]}

Gao, Bo ^{[2
]}

Qiu, Shilun ^{[1
]}

机构：

[1] Jilin Univ, State Key Lab Inorgan Synthesis & Preparat Chem, Changchun 130012, Peoples R China

[2] Jilin Univ, Coll Life Sci, Changchun 130012, Peoples R China

来源：

LANGMUIR | 2009年 / 25卷 / 17期

关键词：

CONTROLLED-RELEASE; GENERALIZED SYNTHESIS; ANIONIC SURFACTANT; CARRIER SYSTEM; MCM-41; COPOLYMER; NANOPARTICLES; MORPHOLOGY; CAPTOPRIL; MIXTURES;

D O I：

10.1021/la900910h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, polymer-mesoporous silica nanoparticles have been synthesized by a dual-template technology. Cationic polymer quaternized poly[bis(2-chloroethyl)ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] (PEPU) and anionic surfactant sodium dodecyl sulfate (SDS) were used to form a homogeneous comicelle system to induce mesoporous silica spherical nanoparticles with diameters of 50-180 nm. The formation mechanism was studied by transmission electron microscopy (TEM), which suggested that PEPU played a cotemplate role in the synthesis process, and no mesoporous structure wits generated without it. After removing the anionic surfactant, SDS, by an ion-exchange method, the cationic polymer-mesoporous silica nanoparticles were obtained. Using the materials as the host and ibuprofen (IBU)/captopril (CapH(2)) as the model drugs, the system revealed well-sustained release profiles.

引用

页码：10159 / 10164

页数：6

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