Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction

被引：81

作者：

Nishida, Keigo ^{[1
,2
]}

Hasegawa, Aiko ^{[1
,3
,4
,5
]}

Nakae, Susumu ^{[6
,7
,8
]}

Oboki, Keisuke ^{[6
,7
]}

Saito, Hirohisa ^{[6
,7
]}

Yamasaki, Satoru ^{[1
]}

Hirano, Toshio ^{[1
,3
,4
,5
]}

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Lab Cytokine Signaling, Kanagawa 2300045, Japan

[2] Osaka Univ, Grad Sch Frontier Biosci, Cooperat Program, Osaka 5650871, Japan

[3] Osaka Univ, Lab Dev Immunol, Osaka 5650817, Japan

[4] Osaka Univ, Core Res Evolut Sci & Technol Program, Japan Sci & Technol Agcy, Grad Sch Frontier Biosci,Grad Sch Med, Osaka 5650817, Japan

[5] Osaka Univ, WPI Immunol Frontier Res Ctr, Osaka 5650817, Japan

[6] Natl Res Inst Child Hlth & Dev, Dept Allergy & Immunol, Tokyo 1578535, Japan

[7] Juntendo Univ, Atopy Res Ctr, Tokyo 1138421, Japan

[8] Univ Tokyo, Inst Med Sci, Frontier Res Initiat, Tokyo 1088639, Japan

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 06期

关键词：

PROTEIN-KINASE-C; TUMOR-NECROSIS-FACTOR; KAPPA-B ACTIVATION; HYPERSENSITIVITY REACTIONS; ALKALINE-PHOSPHATASES; PHORBOL ESTER; EPSILON; IMMUNE; MICE; TNF;

D O I：

10.1084/jem.20082533

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency. However, it remains unknown how Zn homeostasis is regulated in mast cells and if Zn transporters are involved in allergic reactions. We show that Znt5/Slc30a5 is required for contact hypersensitivity and mast cell-mediated delayed-type allergic response but not for immediate passive cutaneous anaphylaxis. In mast cells from Znt5(-/-) mice, Fc epsilon receptor I (Fc epsilon RI)-induced cytokine production was diminished, but degranulation was intact. Znt5 was involved in Fc epsilon RI-induced translocation of protein kinase C (PKC) to the plasma membrane and the nuclear translocation of nuclear factor kappa B. In addition, the Zn finger-like motif of PKC was required for its plasma membrane translocation and binding to diacylglycerol. Thus, Znt5 is selectively required for the mast cell-mediated delayed-type allergic response, and it is a novel player in mast cell activation.

引用

页码：1351 / 1364

页数：14

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