Conservation, acquisition, and functional impact of sex-biased gene expression in mammals

被引：154

作者：

Naqvi, Sahin ^{[1
,2
]}

Godfrey, Alexander K. ^{[1
,2
]}

Hughes, Jennifer F. ^{[1
]}

Goodheart, Mary L. ^{[1
,3
]}

Mitchell, Richard N. ^{[4
]}

Page, David C. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] Whitehead Inst, Howard Hughes Med Inst, Cambridge, MA 02142 USA

[4] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

SCIENCE | 2019年 / 365卷 / 6450期

基金：

美国国家卫生研究院;

关键词：

DOSAGE COMPENSATION; TRANSCRIPTOME; EVOLUTION; CHROMOSOME; GENDER; SPECTRUM; REVEALS; STATURE; TRAITS; SIZE;

D O I：

10.1126/science.aaw7317

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression in human, macaque, mouse, rat, and dog, across 12 tissues. In each tissue, we identified hundreds of genes with conserved sex-biased expression-findings that, combined with genomic analyses of human height, explain similar to 12% of the difference in height between females and males. We surmise that conserved sex biases in expression of genes otherwise operating equivalently in females and males contribute to sex differences in traits. However, most sex-biased expression arose during the mammalian radiation, which suggests that careful attention to interspecies divergence is needed when modeling human sex differences.

引用

页码：249 / +

页数：75

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