Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans

被引：17
作者：
Ban M.
Booth D.
Heard R.
Stewart G.
Goris A.
Vandenbroeck K.
Dubois B.
Laaksonen M.
Ilonen J.
Alizadeh M.
Edan G.
Babron M.C.
Brassat D.
Clanet M.
Cournu-Rebeix I.
Fontaine B.
Semana G.
Goedde R.
Epplen J.
Weber A.
Infante-Duarte C.
Zipp F.
Rajda C.
Bencsik K.
Vécsei L.
Heggarty S.
Graham C.
Hawkins S.
Liguori M.
Momigliano-Richiardi P.
Caputo D.
Grimaldi L.M.
Leone M.
Massacesi L.
Milanese C.
Salvetti M.
Savettieri G.
Trojano M.
Bielecki B.
Mycko M.P.
Selmaj K.
Santos M.
Maciel P.
Pereira C.
Silva A.
Silva B.M.
Coraddu F.
Marrosu M.G.
Akesson E.
Hillert J.
机构：
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 179卷 / 1-2期
基金：
英国惠康基金;
关键词：
JAG1; POU2AF1; linkage disequilibrium; genome screen; meta-analysis; multiple sclerosis;
D O I：
10.1016/j.jneuroim.2006.06.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
By combining all the data available from the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) project, we have been able to identify 17 microsatellite markers showing consistent evidence for apparent association. As might be expected five of these markers map within the Major Histocompatibility Complex (MHC) and are in LD with HLA-DRB1. Individual genotyping of the 12 non-MHC markers confirmed association for three of them - D11S1986, D19S552 and D20S894. Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：108 / 116
页数：9
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