Caspase-8 in cancer biology and therapy

被引：146
作者：
Fulda, Simone [1 ]
机构：
[1] Univ Childrens Hosp, D-89075 Ulm, Germany
来源：
CANCER LETTERS | 2009年 / 281卷 / 02期
关键词：
Apoptosis; Caspase-8; Cancer; SENSITIVE RESPONSE ELEMENT; TRAIL-MEDIATED APOPTOSIS; BREAST-TUMOR CELLS; INTERFERON-GAMMA; NEUROBLASTOMA-CELLS; IFN-GAMMA; GENE-EXPRESSION; DEATH RECEPTOR; UP-REGULATION; EWINGS-SARCOMA;
D O I：
10.1016/j.canlet.2008.11.023
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human diseases. For example, caspase-8 is inactivated in a variety of human cancers, which may promote tumor progression as well as resistance to current treatment approaches. Therefore, caspase-8 presents a promising target to restore defective apoptosis programs in cancels in order to overcome resistance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：128 / 133
页数：6
相关论文
共 77 条
[61]   FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b [J].
Scaffidi, C ;
Medema, JP ;
Krammer, PH ;
Peter, ME .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (43) :26953-26958
[62]   Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility [J].
Senft, Jamie ;
Helfer, Brooke ;
Frisch, Steven M. .
CANCER RESEARCH, 2007, 67 (24) :11505-11509
[63]   Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification [J].
Shivapurkar, N ;
Reddy, J ;
Matta, H ;
Sathyanarayana, UG ;
Huang, CX ;
Toyooka, S ;
Minna, JD ;
Chaudhary, PM ;
Gazdar, AF .
ONCOGENE, 2002, 21 (55) :8510-8514
[64]   Differential inactivation of caspase-8 in lung cancers [J].
Shivapurkar, N ;
Toyooka, S ;
Eby, MT ;
Huang, CX ;
Sathyanarayana, UG ;
Cunningham, HT ;
Reddy, JL ;
Brambilla, E ;
Takahashi, J ;
Minna, JD ;
Choudhary, PM ;
Gazdar, AF .
CANCER BIOLOGY & THERAPY, 2002, 1 (01) :65-69
[65]  
Soung YH, 2005, CANCER RES, V65, P815
[66]   Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis [J].
Stegh, AH ;
Herrmann, H ;
Lampel, S ;
Weisenberger, D ;
Andrä, K ;
Seper, M ;
Wiche, G ;
Krammer, PH ;
Peter, ME .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (15) :5665-5679
[67]   Potentiation of neuroblastoma metastasis by loss of caspase-8 [J].
Stupack, DG ;
Teitz, T ;
Potter, MD ;
Mikolon, D ;
Houghton, PJ ;
Kidd, VJ ;
Lahti, JM ;
Cheresh, DA .
NATURE, 2006, 439 (7072) :95-99
[68]   Get a ligand, get a life: integrins, signaling and cell survival [J].
Stupack, DG ;
Cheresh, DA .
JOURNAL OF CELL SCIENCE, 2002, 115 (19) :3729-3738
[69]   Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma [J].
Takita, J ;
Yang, HW ;
Chen, YY ;
Hanada, R ;
Yamamoto, K ;
Teitz, T ;
Kidd, V ;
Hayashi, Y .
ONCOGENE, 2001, 20 (32) :4424-4432
[70]  
Takita J, 2000, MED PEDIATR ONCOL, V35, P541, DOI 10.1002/1096-911X(20001201)35:6<541::AID-MPO9>3.0.CO
12345678