Caspase-8 in cancer biology and therapy

被引：146
作者：
Fulda, Simone [1 ]
机构：
[1] Univ Childrens Hosp, D-89075 Ulm, Germany
来源：
CANCER LETTERS | 2009年 / 281卷 / 02期
关键词：
Apoptosis; Caspase-8; Cancer; SENSITIVE RESPONSE ELEMENT; TRAIL-MEDIATED APOPTOSIS; BREAST-TUMOR CELLS; INTERFERON-GAMMA; NEUROBLASTOMA-CELLS; IFN-GAMMA; GENE-EXPRESSION; DEATH RECEPTOR; UP-REGULATION; EWINGS-SARCOMA;
D O I：
10.1016/j.canlet.2008.11.023
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human diseases. For example, caspase-8 is inactivated in a variety of human cancers, which may promote tumor progression as well as resistance to current treatment approaches. Therefore, caspase-8 presents a promising target to restore defective apoptosis programs in cancels in order to overcome resistance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：128 / 133
页数：6
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