Synthesis of new 3-cyanoacetamide pyrrole and 3-acetonitrile pyrrole derivatives

被引：34

作者：

Bayat, Mohammad ^{[1
]}

Nasri, Shima ^{[1
]}

Notash, Behrouz ^{[2
]}

机构：

[1] Imam Khomeini Int Univ, Dept Chem, Qazvin, Iran

[2] Shahid Beheshti Univ, Dept Chem, GC, Tehran 1983963113, Iran

来源：

TETRAHEDRON | 2017年 / 73卷 / 11期

关键词：

Aryl glyoxal; One-pot four-component reaction; Fused pyrrole; 3-Cyanoacetamide pyrrole; 3-Acetonitrile pyrrole; FACILE;

D O I：

10.1016/j.tet.2017.02.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new fused heterocyclic derivatives of pyrrole containing acetonitrile or cyanoacetonitrile moiety at 3-position is described by a one-pot multicomponent reaction. The reaction of dimedone, various aniline, aryl glyoxal with malononitrile/ethyl cyanoacetate/methyl cyanoacetate under mild conditions. The present method does not involve any hazardous organic solvents or catalysts. The significant features of this method are readily available starting materials, good yields, and easy purification. (C) 2017 Elsevier Ltd. All rights reserved.

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收藏

页码：1522 / 1527

页数：6

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