Heterotrimeric G proteins in heart disease

被引:19
作者
Zolk, O [1 ]
Kouchi, I [1 ]
Schnabel, P [1 ]
Böhm, M [1 ]
机构
[1] Univ Cologne, Innere Med Klin 3, D-50924 Cologne, Germany
关键词
G proteins; signal transduction; adrenergic system; heart failure; hypertrophy;
D O I
10.1139/cjpp-78-3-187
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Guanine nucleotide binding proteins (G proteins) are largely grouped into three classes: heterotrimeric G proteins, ras-like or small molecular weight GTP binding proteins, and others like G(h). In the heart G proteins transduce signals from a variety of membrane receptors to generate diverse effects on contractility, heart rate, and myocyte growth. This central position of G proteins forming a switchboard between extracellular signals and intracellular effectors makes them candidates possibly involved in the pathogenesis of cardiac hypertrophy, heart failure, and arrhythmia. This review focuses primarily on discoveries of heterotrimeric G protein alterations in heart diseases that help us to understand the pathogenesis and pathophysiology. We also discuss the underlying molecular mechanisms of heterotrimeric G protein signalling.
引用
收藏
页码:187 / 198
页数:12
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