Analgesic Activity of Diterpene Alkaloids from Aconitum Baikalensis

被引：69

作者：

Nesterova, Yu. V. ^{[1
]}

Povet'yeva, T. N. ^{[1
]}

Suslov, N. I. ^{[1
]}

Zyuz'kov, G. N. ^{[1
]}

Pushkarskii, S. V. ^{[1
]}

Aksinenko, S. G. ^{[1
]}

Schultz, E. E. ^{[1
]}

Kravtsova, S. S. ^{[1
]}

Krapivin, A. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, ED Goldberg Res Inst Pharmacol, Siberian Div, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 04期

关键词：

Aconitum baikalensis; diterpene alkaloids; analgesic activity; ANTIINFLAMMATORY ACTIVITY;

D O I：

10.1007/s10517-014-2598-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.

引用

页码：488 / 491

页数：4

共 14 条

[1] Effects of the Aconitum alkaloid mesaconitine in rat hippocampal slices and the involvement of α- and β-adrenoceptors [J].

Ameri, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (02) :243-250

[2]

Bondarenko DA, 2011, BIOMEDITSINA, P84

[3]

Mashkovskii, 2002, DRUGS, V1, P136

[4]

Mironov AN., 2012, handbook for Preclinical Drug Studies

[5] Anti-Inflammatory Activity of Diterpene Alkaloids from Aconitum baikalense [J].

Nesterova, Yu. V. ;

Povetieva, T. N. ;

Suslov, N. I. ;

Zyuz'kov, G. N. ;

Aksinenko, S. G. ;

Pushkarskii, S. V. ;

Krapivin, A. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2014, 156 (05) :665-668

[6] Regeneratory Characteristics of Complex Extract and Isolated Diterpene Alkaloids of Aconitum baikalense [J].

Nesterova, Yu V. ;

Povetieva, T. N. ;

Suslov, N. I. ;

Zhdanov, V. V. ;

Hrichkova, T. Yu ;

Udut, E. V. ;

Chaykovskiy, A. S. ;

Gaydamovich, N. N. ;

Andreeva, T. I. ;

Dygai, A. M. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 152 (04) :439-443

[7] Antidepressant Activity of Diterpene Alkaloids of Aconitum baicalense Turcz [J].

Nesterova, Yu. V. ;

Povetieva, T. N. ;

Suslov, N. I. ;

Semenov, A. A. ;

Pushkarskiy, S. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 151 (04) :425-428

[8]

Nesterova Yu. V., 2009, Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, P30

[9]

Nesterova Yu. V., 2010, VOPR BIOL MED FARM K, P44

[10]

Pashinskii V. G., 2006, Eksperimental'naya i Klinicheskaya Farmakologiya, V69, P55

← 1 2 →