Quantifying the shape of maximal expiratory flow-volume curves in healthy humans and asthmatic patients

被引：13
作者：
Dominelli, Paolo B. [1 ]
Molgat-Seon, Yannick [1 ]
Foster, Glen E. [2 ]
Dominelli, Giulio S. [3 ]
Haverkamp, Hans C. [4 ]
Henderson, William R. [1 ]
Sheel, A. William [1 ]
机构：
[1] Univ British Columbia, Sch Kinesiol, Vancouver, BC V5Z 1M9, Canada
[2] Univ British Columbia, Sch Hlth & Exercise Sci, Ctr Heart Lung & Vasc Hlth, Kelowna, BC, Canada
[3] Univ British Columbia, Kelowna Gen Hosp, Div Resp Med, Kelowna, BC, Canada
[4] Johnson State Coll, Dept Environm & Hlth Sci, Johnson City, VT USA
来源：
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2016年 / 220卷
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
Expiratory flow limitation; Pulmonary system limitation; Ventilator constraints; INDUCED ARTERIAL HYPOXEMIA; EXERCISE HYPERPNEA; VENTILATORY LIMITATION; MECHANICAL CONSTRAINTS; LUNG-FUNCTION; AIR-FLOW; CONFIGURATION; DYSANAPSIS; OBSTRUCTION; VARIABILITY;
D O I：
10.1016/j.resp.2015.09.007
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Differences in the absolute flow and volume of maximal expiratory flow-volume (MEW) curves have been studied extensively in health and disease. However, the shapes of MEW curves have received less attention. We questioned if the MEW curve shape was associated with (i) expiratory flow limitation (EFL) in health and (ii) changes in bronchial caliber in asthmatics. Using the slope-ratio (SR) index, we quantified MEW curve shape in 84 healthy subjects and 8 matched asthmatics. Healthy subjects performed a maximal exercise test to assess EFL. Those with EFL during had a greater SR (1.15 +/- 0.20 vs. 0.85 +/- 0.20, p < 0.05) yet, there was no association between maximal oxygen consumption and SR (r = 0.14, p > 0.05). Asthmatics average SR was greater than the healthy subjects (1.35 +/- 0.03 vs. 0.90 +/- 0.11, p < 0.05), but there were no differences when bronchial caliber was manipulated. In conclusion, a greater SR is related to EFL and this metric could aid in discriminating between groups known to differ in the absolute size of MEW curves. (C) 2015 Elsevier B.V. All rights reserved.
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收藏
页码：46 / 53
页数：8
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