Asymptomatic Intracerebral Hemorrhage May Worsen Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Thrombectomy

被引:39
作者
Jiang, Fang [1 ]
Zhao, Wenbo [1 ]
Wu, Chuanjie [1 ]
Zhang, Zhen [1 ]
Li, Chuanhui [2 ]
Che, Ruiwen [1 ]
Chen, Jian [2 ]
Hu, Weiming [3 ]
Song, Haiqing [1 ]
Duan, Jiangang [1 ]
Ji, Xunming [2 ]
机构
[1] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
[2] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Changchun St 45, Beijing 100053, Peoples R China
[3] Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
Acute ischemic stroke; intracerebral hemorrhage; endovascular thrombectomy; functional outcomes; quality of life; ENDOVASCULAR TREATMENT; MECHANICAL THROMBECTOMY; RISK-FACTORS; TRANSFORMATION; THROMBOLYSIS; ALTEPLASE; REPERFUSION; PREDICTORS; TIROFIBAN; TISSUE;
D O I
10.1016/j.jstrokecerebrovasdis.2019.02.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Asymptomatic intracerebral hemorrhage (AICH) is a common phenomenon in patients with acute ischemic stroke (AIS) who were treated with endovascular thrombectomy (ET). This study aimed to evaluate the clinical effects of AICH and its risk factors in this patient population. Methods: This observational study was based on a prospective registry study. AIS patients with large-vessel occlusion in the anterior circulation and treated with ET were recruited. During thrombectomy procedures, intra-arterial infusion of thrombolytics or antiplatelet and permanent stenting were used as remedial therapies. The primary outcome was the overall distribution of modified Rankin scale (mRS) 90 days after ET. Results: This study included 102 patients (61.1 +/- 12.7 years old), in whom 39 patients (38.2%) experienced AICH. At 90-day follow-up, the median mRS was 2 (interquartile range [IQR] 0-3) for patients without AICH and 4 (IQR 2-6) for those with AICH (adjusted P=.005). Fourteen patients with AICH and 7 patients without AICH died, which was significantly different (35.9% versus 11.1%, adjusted P=.015). Thirty-nine patients (61.9%) without AICH and 14 patients (35.9%) with AICH achieved functional independence at 3-month follow-up (adjusted P=.117). The length of intensive care unit staying was 5 days (IQR 2-10) in patients without AICH and 8 days (IQR 3-19) in those with AICH (adjusted P=.840). In multivariate analysis, lower Alberta Stroke Program Early CT Score (ASPECTS) (adjusted P=.003) and adjunctively intra-arterial thrombolysis (adjusted P=.016) were independently associated with AICH. Conclusions: In AIS patients treated with ET AICH appears to be associated with worse functional outcomes and high mortality. Lower ASPECTS and adjectively intra-arterial thrombolysis were independent risk factors of AICH.
引用
收藏
页码:1752 / 1758
页数:7
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