An electroactive hybrid biointerface for enhancing neuronal differentiation and axonal outgrowth on bio-subretinal chip

被引：11
作者：
Yang, Jia-Wei [1 ,2 ]
Chen, Chong-You [1 ,2 ]
Yu, Zih-Yu [1 ]
Chung, Johnson H. Y. [3 ]
Liu, Xiao [3 ]
Wu, Chung-Yu [4 ]
Chen, Guan-Yu [1 ,2 ]
机构：
[1] Natl Yang Ming Chiao Tung Univ, Coll Elect & Comp Engn, Inst Biomed Engn, Hsinchu 300093, Taiwan
[2] Natl Yang Ming Chiao Tung Univ, Coll Elect & Comp Engn, Dept Elect & Elect Engn, Hsinchu 300093, Taiwan
[3] Univ Wollongong, ARC Ctr Excellence Electromat Sci, Intelligent Polymer Res Inst, Wollongong, NSW 2500, Australia
[4] Natl Yang Ming Chiao Tung Univ, Inst Elect, Hsinchu 300093, Taiwan
来源：
MATERIALS TODAY BIO | 2022年 / 14卷
基金：
澳大利亚研究理事会;
关键词：
Graphene oxide; Biointerface; Neuronal cell; Retinal chip; Micropattern; RETINAL PROSTHESIS; GRAPHENE; OXIDE; CELL; ELECTRODES; REDUCTION;
D O I：
10.1016/j.mtbio.2022.100253
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Retinal prostheses offer viable vision restoration therapy for patients with blindness. However, a critical requirement for maintaining the stable performance of electrical stimulation and signal transmission is the biocompatibility of the electrode interface. Here, we demonstrated a functionalized electrode-neuron biointerface composed of an annealed graphene oxide-collagen (aGO-COL) composite and neuronal cells. The aGO-COL exhibited an electroactive 3D crumpled surface structure and enhanced the differentiation efficiency of PC-12 cells. It is integrated into a photovoltaic self-powered retinal chip to develop a biohybrid retinal implant that facilitates biocompatibility and tissue regeneration. Moreover, aGO-COL micropatterns fabricated via 3D bio-printing can be used to create neuronal cell microarrays, which supports the possibility of retaining the high spatial resolution achieved through electrical stimulation of the retinal chip. This study paves the way for the next generation of biohybrid retinal implants based on biointerfaces.
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页数：10
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