Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

被引：28

作者：

Eftekhari, Sanaz ^{[1
,2
,3
]}

Shahrokhi, Amene ^{[1
,2
,3
]}

Tsintsadze, Vera ^{[1
,2
]}

Nardou, Romain ^{[3
]}

Brouchoud, Corinne ^{[1
,2
]}

Conesa, Magali ^{[3
]}

Burnashev, Nail ^{[1
,2
]}

Ferrari, Diana C. ^{[3
]}

Ben-Ari, Yehezkel ^{[1
,2
,3
]}

机构：

[1] INSERM, U901, Mediterranean Inst Neurobiol INMED, F-13258 Marseille, France

[2] Aix Marseille Univ, UMR 901, Marseille, France

[3] Neurochlore, Marseille, France

来源：

SCIENCE | 2014年 / 346卷 / 6206期

关键词：

ANIMAL-MODEL; MOUSE MODEL; BEHAVIORS;

D O I：

10.1126/science.1256009

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of gamma-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.

引用

页数：2

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