Associations of urinary phenolic environmental estrogens exposure with blood glucose levels and gestational diabetes mellitus in Chinese pregnant women

被引：29

作者：

Hou, Yaxing ^{[1
]}

Li, Shuying ^{[2
]}

Xia, Liting ^{[1
]}

Yang, Qiaoyun ^{[1
]}

Zhang, Liwen ^{[1
]}

Zhang, Xumei ^{[3
]}

Liu, Huihuan ^{[4
]}

Huo, Ran ^{[4
]}

Cao, Guanghan ^{[4
]}

Huang, Chunyun ^{[4
]}

Tian, Xiubiao ^{[2
]}

Sun, Lirong ^{[5
,6
]}

Cao, Deqing ^{[7
]}

Zhang, Ming ^{[8
]}

Zhang, Qiang ^{[1
]}

Tang, Naijun ^{[1
]}

机构：

[1] Tianjin Med Univ, Tianjin Key Lab Environm Nutr & Publ Hlth, Dept Occupat & Environm Hlth, Sch Publ Hlth, Tianjin, Peoples R China

[2] Tianjin Xiqing Hosp, Dept Endocrinol, Tianjin, Peoples R China

[3] Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Sci, Tianjin, Peoples R China

[4] Beichen Dist Womens & Childrens Hlth Ctr, Tianjin, Peoples R China

[5] Tianjin Med Univ, Chu Hsien I Mem Hosp, Tianjin Key Lab Metabol Dis, NHC Key Lab Hormones & Dev, Tianjin, Peoples R China

[6] Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin, Peoples R China

[7] Tianjin Med Univ, Sch Publ Hlth, Cent Lab Prevent Med, Tianjin, Peoples R China

[8] Tianjin Ctr Dis Control & Prevent, Tianjin, Peoples R China

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2021年 / 754卷

关键词：

Endocrine-disrupting chemicals; Bisphenol A; Nonylphenol; Octylphenol; Glucose intolerance; Gestational exposure; BISPHENOL-A EXPOSURE; NONYLPHENOL EXPOSURE; PRENATAL EXPOSURE; BIRTH OUTCOMES; COHORT; PHTHALATE; METABOLISM; TOXICITY; 4-TERT-OCTYLPHENOL; SUSCEPTIBILITY;

D O I：

10.1016/j.scitotenv.2020.142085

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Endocrine-disrupting chemicals (EDCs) are considered to be related to diabetes, but studies of the association between phenolic EDCs and gestational diabetes mellitus (GDM) are limited. Objectives: To assess associations of maternal urinary bisphenol A (BPA), nonylphenol (NP), and 2-tertoctylphenol (2-t-OP) with GDM occurrence. Methods: A cross-sectional study was performed among 390 Chinese women at 24-28 weeks of gestation. GDM was diagnosed with a 2-h 75-g oral glucose tolerance test (OGTT). BPA, NP, and 2-t-OP concentrations were determined in urine samples. Linear and logistic regression tests evaluated associations of BPA, NP, and 2-t-OP with blood glucose levels and GDM prevalence. Results: The 2-t-OP concentrations in GDM patients were significantly higher than in non-GDM women with me-dian values of 2.23 mu g/g Cr and 1.79 mu g/g Cr, respectively. No significant difference was observed in BPA and NP. Urinary 2-t-OP was positively associated with blood glucose levels after adjustment for several confounding fac-tors and urinary BPA and NP. Higher 2-t-OP levels were associated with higher odds of GDM (OR: 5.78; 95% CI: 2.04, 16.37), whereas higher NP levels were associated with lower odds (OR: 0.22; 95% CI: 0.05, 0.85) in the ad-justed models. In addition, compared to the first quartile of 2-t-OP, the adjusted odds ratios (ORs) and 95% con-fidence intervals (95% CIs) for GDM in the second, third, and fourth quartiles were 2.81 (1.23, 6.42), 3.01 (1.30, 6.93), and 5.49 (2.24, 13.46), respectively. Conclusion: Our study indicates that, for the first time to our knowledge, exposure to 2-t-OP is associated with a higher risk of GDM. However, higher NP exposure is associated with lower GDM risk. Further studies are neces-sary to affirm the associations of 2-t-OP and NP with GDM, and to elucidate the causality of these findings. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：9

共 31 条

[31] Correlation between inflammatory markers (hs-CRP, TNF-α, IL-1β, IL-6, IL-18), glucose intolerance, and gestational diabetes mellitus in pregnant women
Zhao, Xiaolei
Liu, Junli
Shen, Lili
Wang, Aiqin
Wang, Rui
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (08): : 8310 - 8316

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