Mycoplasma penetrans is capable of activating Vγ9/Vδ2 T cells while other human pathogenic mycoplasmas fail to do so

被引：19
作者：
Eberl, M
Hintz, M
Jamba, Z
Beck, E
Jomaa, H
Christiansen, G
机构：
[1] Univ Giessen, Inst Biochem, D-35392 Giessen, Germany
[2] Univ Aarhus, Inst Med Microbiol & Immunol, DK-8000 Aarhus C, Denmark
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 08期
关键词：
D O I：
10.1128/IAI.72.8.4881-4883.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human Vgamma9/Vdelta2 T cells.
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收藏
页码：4881 / 4883
页数：3
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