A multi-agent model describing self-renewal of differentiation effects on the blood cell population

被引：12
作者：
Bessonov, Nikolai [2 ]
Demin, Ivan [1 ]
Pujo-Menjouet, Laurent [1 ]
Volpert, Vitaly [1 ]
机构：
[1] Univ Lyon 1, CNRS, Inst Camille Jordan, UMR 5208, F-69222 Villeurbanne, France
[2] Inst Mech Engn Problems, St Petersburg 199178, Russia
来源：
MATHEMATICAL AND COMPUTER MODELLING | 2009年 / 49卷 / 11-12期
关键词：
Hematopoiesis; Anemia; Multi-agent model; Self-renewal; Cell communication; CHRONIC MYELOGENOUS LEUKEMIA; ERYTHROID PROGENITOR CELLS; HEMATOPOIETIC STEM-CELLS; CYCLICAL NEUTROPENIA; MATHEMATICAL-MODEL; PERIODIC OSCILLATIONS; LINEAGE SPECIFICATION; DIVISION;
D O I：
10.1016/j.mcm.2008.07.023
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
In this work, a new multi-agent model is used to describe blood cell population dynamics. More particularly, we focus our simulations here on differentiation and self-renewal process based on cell communication. We consider the different cases where progenitor cells are able to self-renew or not in the bone marrow. As a consequence of this study, we give some possible explanations of the mechanism for recovery of the system under important blood loss or blood diseases such as anemia. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2116 / 2127
页数：12
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