Nickel-Catalyzed [4+2] Annulation of Nitriles and Benzylamines by C-H/N-H Activation

被引：23

作者：

Sikari, Rina ^{[1
]}

Chakraborty, Gargi ^{[1
]}

Guin, Amit Kumar ^{[1
]}

Paul, Nanda D. ^{[1
]}

机构：

[1] Indian Inst Engn Sci & Technol, Dept Chem, Howrah 711103, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 01期

关键词：

2-SUBSTITUTED QUINAZOLINES; C(SP(3))-H BONDS; FUNCTIONALIZATION; ALKYLATION; ARYLATION; AMIDES; ALKENYLATION; COMPLEXES; OXIDATION; STRATEGY;

D O I：

10.1021/acs.joc.0c02069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nickel-catalyzed [4 + 2] annulation of benzylamines and nitriles via C-H/N-H bond activation, providing straightforward atom-economic access to a wide variety of multisubstituted quinazolines, is reported. Mechanistic investigation revealed that the in situ formed amidines from the coupling of benzylamines and nitriles direct the nickel catalyst to activate the ortho-C-H bond of the phenyl ring of the benzylamine.

引用

页码：279 / 290

页数：12

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