Is mPGES-1 a promising target for pain therapy?

被引：47
作者：
Scholich, Klaus [1 ]
Geisslinger, Gerd [1 ]
机构：
[1] Univ Frankfurt Klinikum, Pharmazentrum Frankfurt, ZAFES, D-60590 Frankfurt, Germany
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 08期
关键词：
D O I：
10.1016/j.tips.2006.06.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cyclooxygenase (COX) inhibitors are widely used analgesic and anti-inflammatory drugs. Owing to undesirable effects caused by unselective COX inhibitors and selective COX-2 inhibitors, microsomal prostaglandin E-2 synthase-1 has been considered as an alternative target for the development of analgesic drugs. However, recent findings question the usefulness of this terminal synthase as a promising drug target for pain therapy.
引用
收藏
页码：399 / 401
页数：3
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