Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

被引：21

作者：

Jeong, Eun Hye ^{[1
]}

Ryu, Ji Hyun ^{[2
]}

Jeong, Hansaem ^{[1
]}

Jang, Bora ^{[1
]}

Lee, Ho Yeon ^{[1
]}

Hong, Seonki ^{[2
]}

Lee, Haeshin ^{[2
]}

Lee, Hyukjin ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 120750, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 87期

基金：

新加坡国家研究基金会;

关键词：

SURFACE-CHEMISTRY; NANOPARTICLES; DNA; RELEASE; CELLS;

D O I：

10.1039/c4cc07155g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.

引用

页码：13388 / 13390

页数：3

共 19 条

[1] Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates [J].

Braun, Gary B. ;

Pallaoro, Alessia ;

Wu, Guohui ;

Missirlis, Dimitris ;

Zasadzinski, Joseph A. ;

Tirrell, Matthew ;

Reich, Norbert O. .

ACS NANO, 2009, 3 (07) :2007-2015

[2] Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates [J].

Choi, Chung Hang J. ;

Hao, Liangliang ;

Narayan, Suguna P. ;

Auyeung, Evelyn ;

Mirkin, Chad A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) :7625-7630

[3] One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering [J].

Ejima, Hirotaka ;

Richardson, Joseph J. ;

Liang, Kang ;

Best, James P. ;

van Koeverden, Martin P. ;

Such, Georgina K. ;

Cui, Jiwei ;

Caruso, Frank .

SCIENCE, 2013, 341 (6142) :154-157

[4]

Ekici, 2008, J PHYS D, V41

[5] Gold Nanoparticles for Biology and Medicine [J].

Giljohann, David A. ;

Seferos, Dwight S. ;

Daniel, Weston L. ;

Massich, Matthew D. ;

Patel, Pinal C. ;

Mirkin, Chad A. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (19) :3280-3294

[6] Pyrogallol 2-Aminoethane: A Plant Flavonoid-Inspired Molecule for Material-Independent Surface Chemistry [J].

Hong, Seonki ;

Yeom, Jihyeon ;

Song, In Taek ;

Kang, Sung Min ;

Lee, Hyukjin ;

Lee, Haeshin .

ADVANCED MATERIALS INTERFACES, 2014, 1 (04)

[7] Poly(norepinephrine): Ultrasmooth Material-Independent Surface Chemistry and Nanodepot for Nitric Oxide [J].

Hong, Seonki ;

Kim, Jihoon ;

Na, Yun Suk ;

Park, Junghong ;

Kim, Sunjin ;

Singha, Kaushik ;

Im, Gun-Il ;

Han, Dong-Keun ;

Kim, Won Jong ;

Lee, Haeshin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (35) :9187-9191

[8] Determination of the minimum temperature required for selective photothermal destruction of cancer cells with the use of immunotargeted gold nanoparticles [J].

Huang, XH ;

Jain, PK ;

El-Sayed, IH ;

El-Sayed, MA .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2006, 82 (02) :412-417

[9] Maximizing DNA loading on a range of gold nanoparticle sizes [J].

Hurst, Sarah J. ;

Lytton-Jean, Abigail K. R. ;

Mirkin, Chad A. .

ANALYTICAL CHEMISTRY, 2006, 78 (24) :8313-8318

[10] Light-Induced Release of DNA from Gold Nanoparticles: Nanoshells and Nanorods [J].

Huschka, Ryan ;

Zuloaga, Jorge ;

Knight, Mark W. ;

Brown, Lisa V. ;

Nordlander, Peter ;

Halas, Naomi J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (31) :12247-12255

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