The Structural Consequences of Calcium Crystal Deposition

被引：14
作者：
Durcan, Laura [1 ]
Bolster, Ferdia [2 ]
Kavanagh, Eoin C. [2 ]
McCarthy, Geraldine M. [1 ]
机构：
[1] Mater Misericordiae Univ Hosp, Div Rheumatol, Dublin 7, Ireland
[2] Mater Misericordiae Univ Hosp, Dept Radiol, Dublin 7, Ireland
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2014年 / 40卷 / 02期
关键词：
Calcium crystals; Basic calcium phosphate; Calcium pyrophosphate dihydrate; Arthritis; Vascular calcification; Atherosclerosis; SYNOVIAL-FLUID CRYSTALS; NECROSIS-FACTOR-ALPHA; ROTATOR CUFF DEFECTS; PHOSPHATE CRYSTALS; HYDROXYAPATITE CRYSTALS; MILWAUKEE SHOULDER; KNEE CHONDROCALCINOSIS; PATHOLOGICAL FEATURES; ACTIVE COLLAGENASE; HUMAN FIBROBLASTS;
D O I：
10.1016/j.rdc.2014.01.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Calcium pyrophosphate dihydrate and basic calcium phosphate (BCP) crystals are the most common calcium-containing crystals associated with rheumatic disease. Clinical manifestations of calcium crystal deposition include acute or chronic inflammatory and degenerative arthritides and certain forms of periarthritis. The intra-articular presence of BCP crystals correlates with the degree of radiographic degeneration. Calcium crystal deposition contributes directly to joint degeneration. Vascular calcification is caused by the deposition of calcium hydroxyapatite crystals in the arterial intima. These deposits may contribute to local inflammation and promote further calcification, thus aggravating the atherosclerotic process. Calcium crystal deposition results in substantial structural consequence in humans.
引用
收藏
页码：311 / +
页数：19
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