Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas

被引：22
作者：
Tamaoki, J
Nakata, J
Tagaya, E
Konno, K
机构：
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 07期
关键词：
D O I：
10.1128/AAC.40.7.1726
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Inhaled interleukin 8 caused an increase in goblet cell secretion in guinea pig tracheas, which was accompanied by mucosal infiltration of neutrophils, These responses were inhibited by pretreatment with roxithromycin or erythromycin in a dose-dependent fashion, Macrolides may thus be of value in protecting against neutrophil-associated airway hypersecretion.
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页码：1726 / 1728
页数：3
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