The evolution of the unstable cancer genome

被引：47

作者：

Burrell, Rebecca A. ^{[1
]}

Swanton, Charles ^{[1
,2
]}

机构：

[1] Canc Res UK London Res Inst, Translat Canc Therapeut Lab, London WC2A 3LY, England

[2] UCL Canc Inst, London WC1E 6DD, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 24卷

基金：

英国医学研究理事会;

关键词：

ACUTE MYELOID-LEUKEMIA; 21 BREAST CANCERS; CELL LUNG-CANCER; MUTATIONAL PROCESSES; CLONAL EVOLUTION; INTRATUMOR HETEROGENEITY; PANCREATIC-CANCER; DNA-POLYMERASE; FRAGILE SITES; INSTABILITY;

D O I：

10.1016/j.gde.2013.11.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer next-generation sequencing and genomics studies published over the last five years have provided unprecedented insights into the forces shaping cancer genome evolution. In particular, these studies have revealed a high level of heterogeneity not only between different tumours, but also within individual tumours; the 'cancer genome' may evolve along several independent trajectories within a single tumour. There is an increasing appreciation of the importance of intratumour genetic heterogeneity in determining disease progression and clinical outcome in cancer medicine, and thus an increasing awareness of the need to understand the processes that both generate genetic diversity and shape genome evolution in human tumours.

引用

页码：61 / 67

页数：7

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