Upregulation of integrin expression on monocytes in multiple sclerosis patients treated with natalizumab

被引：7

作者：

Dallari, Simone ^{[1
]}

Franciotta, Diego ^{[2
]}

Carluccio, Silvia ^{[1
]}

Signorini, Lucia ^{[1
]}

Gastaldi, Matteo ^{[2
]}

Colombo, Elena ^{[2
]}

Bergamaschi, Roberto ^{[2
]}

Elia, Francesca ^{[1
]}

Villani, Sonia ^{[1
]}

Ferrante, Pasquale ^{[1
,3
]}

Delbue, Serena ^{[1
]}

机构：

[1] Univ Milan, Dept Biomed Surg & Dent Sci, I-20133 Milan, Italy

[2] Natl Neurol Inst C Mondino, Dept Gen Neurol, Pavia, Italy

[3] Hlth Sci Fdn, Fdn Ettore Sansavini, Lugo, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 287卷

关键词：

Multiple sclerosis; Natalizumab; Monocytes; ANTIBODY NATALIZUMAB; CELLS; MECHANISMS; BIOMARKER; RISK;

D O I：

10.1016/j.jneuroim.2015.08.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natalizumab is a humanized monoclonal antibody against the alpha 4 subunit of VLA-4 integrin that is used to treat conditions such as multiple sclerosis (MS). Although its effects on lymphocytes have been widely described, little is known about its effects on monocytes. Here we described the effects of natalizumab treatment on peripheral blood monocytes from a small cohort of MS patients in terms of relative frequencies and surface integrin (CD49d and CD18) expression. We showed that natalizumab treatment altered the surface integrin expression on monocyte subsets in the peripheral compartment, suggesting a role for them as mediators of natalizumab effects. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：76 / 79

页数：4

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