1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review

被引：47

作者：

Kumar, Rajeev ^{[1
]}

Singh, Amar Deep ^{[1
]}

Singh, Jitendra ^{[1
]}

Singh, Hariram ^{[1
]}

Roy, R. K. ^{[1
]}

Chaudhary, Anurag ^{[2
]}

机构：

[1] Dr KN Modi Inst Pharmaceut Educ & Res, Ghaziabad 201201, UP, India

[2] Meerut Inst Engn & Technol, Dept Pharmaceut Technol, Meerut 250005, Uttar Pradesh, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2014年 / 14卷 / 01期

关键词：

Anticancer activity; antimicrobial activity; antiprotozoal; in vivo; 1,2,3-triazine; BENZOTRIAZINE BASED COMPOUNDS; NEMATOCIDAL ACTIVITY; CYTOTOXIC ACTIVITY; KINASE INHIBITOR; ANTITUMOR; DERIVATIVES; SERIES; 6-AZAURIDINE; ANALOGS; DESIGN;

D O I：

10.2174/1389557513666140103111017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,2,3-Triazine is an interesting class of heterocyclic compounds. Various synthetic analogs of 1,2,3-triazine have been prepared and evaluated for many pharmacological activities in different models with desired findings. Some analogs have shown potent pharmacological activity and may be considered as lead molecule for the development of future drugs. This review is an attempt to organize the chemical and pharmacological aspects of 1,2,3-triazine analogs reported till date systematically since 1970.

引用

页码：72 / 83

页数：12

共 50 条

[21] Discovery of 7-Methyl-10-Hydroxyhomocamptothecins with 1,2,3-Triazole Moiety as Potent Topoisomerase I Inhibitors
Xu, Xiguo
Wu, Yuelin
Liu, Wenfeng
Sheng, Chuanquan
Yao, Jianzhong
Dong, Guoqiang
Fang, Kun
Li, Jin
Yu, Zhiliang
Min, Xiao
Zhang, Huojun
Miao, Zhenyuan
Zhang, Wannian
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 88 (03) : 398 - 403
[22] 1,2,3-Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review
Singh, Atamjit
Singh, Karanvir
Sharma, Aman
Joshi, Kaustubh
Singh, Brahmjeet
Sharma, Sambhav
Batra, Kevin
Kaur, Kirandeep
Singh, Dilpreet
Chadha, Renu
Bedi, Preet Mohinder Singh
CHEMISTRY & BIODIVERSITY, 2023, 20 (05)
[23] Synthesis, characterization, insecticidal activity and antibacterial evaluation of some heterocyclic compounds containing 1,2,3-triazoles moiety
Khalaf, Mai M.
Abd El-Lateef, Hany M.
Gouda, Mohamed
Ibrahim, Tamer Mohamed Abdelghani
El-Shamy, Hemdan
Abdelhamid, Antar A.
AL-Ghamdi, Saleh
Amer, Amer A.
Alam, Mohammad Mahboob
Gad, Mohamed A.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2024, 101 (12)
[24] Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor
Wang, Hsiao-Chun
Jagtap, Ajit Dhananjay
Chang, Pei-Teh
Liu, Jia-Rong
Liu, Chih-Peng
Tseng, Hsiang-Wen
Chen, Grace Shiahuy
Chern, Ji-Wang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 84 : 312 - 334
[25] Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity
Dao, Pascal
Lietha, Daniel
Etheve-Quelquejeu, Melanie
Garbay, Christiane
Chen, Huixiong
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (08) : 1727 - 1730
[26] 1,3-Oxazine as a Promising Scaffold for the Development of Biologically Active Lead Molecules
Gupta, Nidhi
Saini, Vipin
Basavarajaiah, S. M.
Dar, Mohammad Ovais
Das, Rina
Dahiya, Randhir Singh
CHEMISTRYSELECT, 2023, 8 (39):
[27] Synthesis and Crystal Structure of New Heterocyclic Compounds Containing 1,2,3-Triazole Moiety
Dong, Zhi-Qiang
Liu, Fang-Ming
Zeng, Yong-Ming
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2011, 41 (08) : 1158 - 1164
[28] Synthesis and in Silico Studies of Some New 1,2,3-Triazolyltetrazole Bearing Indazole Derivatives as Potent Antimicrobial Agents
Gujja, Venkanna
Sadineni, Kumaraswamy
Epuru, Manohar Reddy
Rao Allaka, Tejeswara
Banothu, Venkanna
Gunda, Shravan Kumar
Koppula, Shiva Kumar
CHEMISTRY & BIODIVERSITY, 2023, 20 (12)
[29] [1,2,3]Triazolo[4,5-d]pyrimidine derivatives incorporating (thio)urea moiety as a novel scaffold for LSD1 inhibitors
Li, Zhong-Hua
Ma, Jin-Lian
Liu, Gai-Zhi
Zhang, Xin-Hui
Qin, Ting-Ting
Ren, Wei-Hong
Zhao, Tao-Qian
Chen, Xiao-Hui
Zhang, Zhen-Qiang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 187
[30] 1,2,4-Triazole: A Privileged Scaffold for the Development of Potent Antifungal Agents - A Brief Review
Tratrat, Christophe
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2020, 20 (24) : 2235 - 2258

← 1 2 3 4 5 →