1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review

被引：47

作者：

Kumar, Rajeev ^{[1
]}

Singh, Amar Deep ^{[1
]}

Singh, Jitendra ^{[1
]}

Singh, Hariram ^{[1
]}

Roy, R. K. ^{[1
]}

Chaudhary, Anurag ^{[2
]}

机构：

[1] Dr KN Modi Inst Pharmaceut Educ & Res, Ghaziabad 201201, UP, India

[2] Meerut Inst Engn & Technol, Dept Pharmaceut Technol, Meerut 250005, Uttar Pradesh, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2014年 / 14卷 / 01期

关键词：

Anticancer activity; antimicrobial activity; antiprotozoal; in vivo; 1,2,3-triazine; BENZOTRIAZINE BASED COMPOUNDS; NEMATOCIDAL ACTIVITY; CYTOTOXIC ACTIVITY; KINASE INHIBITOR; ANTITUMOR; DERIVATIVES; SERIES; 6-AZAURIDINE; ANALOGS; DESIGN;

D O I：

10.2174/1389557513666140103111017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,2,3-Triazine is an interesting class of heterocyclic compounds. Various synthetic analogs of 1,2,3-triazine have been prepared and evaluated for many pharmacological activities in different models with desired findings. Some analogs have shown potent pharmacological activity and may be considered as lead molecule for the development of future drugs. This review is an attempt to organize the chemical and pharmacological aspects of 1,2,3-triazine analogs reported till date systematically since 1970.

引用

页码：72 / 83

页数：12

共 53 条

[21] PTK 787/ZK 222584, a tyrosine kinase inhibitor of all known VEGF receptors, represses tumor growth with high efficacy [J].

Hess-Stumpp, H ;

Haberey, M ;

Thierauch, KH .

CHEMBIOCHEM, 2005, 6 (03) :550-557

[22] Synthesis and SAR studies of novel antifungal 1,2,3-triazines [J].

Hunt, James C. A. ;

Briggs, Emma ;

Clarke, Eric D. ;

Whittingham, William G. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (18) :5222-5226

[23]

Kar A., 2010, MED CHEM, V5th

[24] NEMATOCIDAL ACTIVITY OF LONG ALKYL CHAIN AMIDES, AMINES, AND THEIR DERIVATIVES ON DOG ROUNDWORM LARVAE [J].

KIUCHI, F ;

NISHIZAWA, S ;

KAWANISHI, H ;

KINOSHITA, S ;

OHSIMA, H ;

UCHITANI, A ;

SEKINO, N ;

ISHIDA, M ;

KONDO, K ;

TSUDA, Y .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (12) :3234-3244

[25]

KOBARI K, 1970, Bulletin of the World Health Organization, V43, P365

[26] Synthesis of 4-substituted imidazo[4,5-d][1,2,3]triazine (2-azapurine)nucleosides [J].

Krawczyk, S ;

Migawa, MT ;

Drach, JC ;

Townsend, LB .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2000, 19 (1-2) :39-68

[27] Synthesis and cytotoxicity evaluation of (tetrahydro-β-carboline)-1,3,5-triazine hybrids as anticancer agents [J].

Kumar, Ravi ;

Gupta, Leena ;

Pal, Pooja ;

Khan, Shahnawaz ;

Singh, Neetu ;

Katiyar, Sanjay Babu ;

Meena, Sanjeev ;

Sarkar, Jayanta ;

Sinha, Sudhir ;

Kanaujiya, Jitendra Kumar ;

Lochab, Savita ;

Trivedi, Arun Kumar ;

Chauhan, Prem M. S. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (06) :2265-2276

[28] Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor [J].

Li, Hui ;

Tatlock, John ;

Linton, Angelica ;

Gonzalez, Javier ;

Jewell, Tanya ;

Patel, Leena ;

Ludlum, Sarah ;

Drowns, Matthew ;

Rahavendran, Sadayappan V. ;

Skor, Heather ;

Hunter, Robert ;

Shi, Stephanie T. ;

Herlihy, Koleen J. ;

Parge, Hans ;

Hickey, Michael ;

Yu, Xiu ;

Chau, Fannie ;

Nonomiya, Jim ;

Lewis, Cristina .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (05) :1255-1258

[29] Design, synthesis, and antitumor activities of some novel substituted 1,2,3-benzotriazines [J].

Lv, Jin-Ling ;

Wang, Rui ;

Liu, Dan ;

Guo, Gang ;

Jing, Yong-Kui ;

Zhao, Lin-Xiang .

MOLECULES, 2008, 13 (06) :1427-1440

[30] In vitro cytotoxic activities of 2-alkyl-4,6-diheteroalkyl-1,3,5-triazines: New molecules in anticancer research [J].

Menicagli, R ;

Samaritani, S ;

Signore, G ;

Vaglini, F ;

Via, LD .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (19) :4649-4652

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