Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity

被引：17

作者：

Li, Siwen ^{[1
]}

Niu, Huanmin ^{[2
]}

Qiao, Yanan ^{[1
]}

Zhu, Rongxiu ^{[3
]}

Sun, Yong ^{[1
]}

Ren, Zhaojie ^{[4
]}

Yuan, Huiqing ^{[2
]}

Gao, Yun ^{[1
]}

Li, Yi ^{[1
]}

Chen, Wang ^{[5
]}

Zhou, Jinchuan ^{[1
]}

Lou, Hongxiang ^{[1
]}

机构：

[1] Shandong Univ, Minist Educ, Key Lab Chem Biol, Dept Nat Prod Chem, 44 West Wenhua Rd, Jinan 250010, Shandong, Peoples R China

[2] Shandong Univ, Sch Med, Dept Biochem & Mol Biol, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Sch Chem & Chem Engn, Jinan, Shandong, Peoples R China

[4] Shandong Museum, Nat Dept, 11899 Jingshi Rd, Jinan, Shandong, Peoples R China

[5] Shanxi Univ Technol, Vitamin Res Inst D, 1 Dongyi Rd, Hanzhong 723000, Shanxi, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2018年 / 26卷 / 09期

关键词：

Liverworts; Terpenoids; Anti-inflammatory; NF-KAPPA-B; EUDESMANE-TYPE SESQUITERPENOIDS; KAURANE-TYPE DITERPENOIDS; DOLABELLANE DITERPENOIDS; INFLAMMATORY RESPONSES; JUNGERMANNIA-SUBULATA; CHEMICAL-CONSTITUENTS; SALVIA-PLEBEIA; BRYOPHYTES; CELLS;

D O I：

10.1016/j.bmc.2018.03.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new terpenoids (1-5) including two dollabellane-type, one ent-kaurane-type diterpenoids and two sesquiterpenoids were isolated from the Chinese liverwort Lepidozia reptans (L.) Dumort., together with nine known terpenoids (6-14). Their structures were determined on the basis of analysis of MS and NMR spectroscopic data, single-crystal X-ray diffraction and electronic circular dichroism calculations. The selected compounds 1, 2, 6, 7, 9 and 14 were screened for anti-inflammatory activities by the model of LPS-induced nitric oxide (NO) production with macrophage cells, and the mechanism of the active compounds 1 and 2 were further explored. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2392 / 2400

页数：9

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