A New Enantioselective Synthesis of the Anti-Parkinson Agent Safinamide

被引：14

作者：

Reddi, Anjaneyulu ^{[1
]}

Mujahid, Mohammad ^{[1
]}

Sasikumar, Murugesan ^{[1
]}

Muthukrishnan, Murugan ^{[1
]}

机构：

[1] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 13期

关键词：

medicinal chemistry; stereoselective synthesis; amides; safinamide; HYDROLYTIC KINETIC RESOLUTION; TERMINAL EPOXIDES; DRUG; DISEASE; ANALOGS;

D O I：

10.1055/s-0033-1341104

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from simple, commercially available, starting materials is described. The protocol might also be useful in the synthesis of structural variants of safinamide, such as ralfinamide or related analogues

引用

页码：1751 / 1756

页数：6

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