Maternal, placental and fetal exposure to bisphenol A in women with and without preeclampsia

被引：48
作者：
Leclerc, Francois [1 ]
Dubois, Marie-France [2 ]
Aris, Aziz [1 ]
机构：
[1] Univ Sherbrooke, CHUS, Fac Med & Hlth Sci, Dept Obstet & Gynecol, Sherbrooke, PQ J1H 5N4, Canada
[2] Univ Sherbrooke, CHUS, Fac Med & Hlth Sci, Dept Community Hlth Sci, Sherbrooke, PQ J1H 5N4, Canada
来源：
HYPERTENSION IN PREGNANCY | 2014年 / 33卷 / 03期
关键词：
Bisphenol A; Fetal blood; Maternal blood; Placenta; Preeclampsia; TROPHOBLAST DEPORTATION; ERR-GAMMA; PATHOGENESIS; EXPRESSION; PREGNANCIES; APOPTOSIS; TISSUE; CELLS; SERUM;
D O I：
10.3109/10641955.2014.892607
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objectives: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. Methods: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method. Results: BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown. Conclusions: This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta.
引用
收藏
页码：341 / 348
页数：8
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