New functions of cholesterol binding proteins

被引：18

作者：

Liu, Jun-Ping ^{[1
]}

机构：

[1] Monash Univ, Cent Clin School, Dept Immunol, Prahran, Vic 3181, Australia

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 303卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Cholesterol binding protein; LXR; NPC1; Mechanisms; LIVER-X-RECEPTORS; STEROL-SENSING DOMAIN; CLEAVAGE-ACTIVATING PROTEIN; PURIFIED NPC1 PROTEIN; CRYSTAL-STRUCTURE; ENDOPLASMIC-RETICULUM; REGULATED TRANSPORT; C2; PROTEIN; LXR-ALPHA; DISEASE;

D O I：

10.1016/j.mce.2009.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cholesterol is an essential component of eukaryotic cell membranes with an important role in signal transduction. Although cholesterol can operate to auto-regulate its own disposal via gene transcriptional mechanisms, glucose also binds to the same cholesterol-binding transcription factors to regulate gene expression. Different sterol binding proteins bind different lipids to regulate both lipid homeostasis and antigen presentation. This mini-review examines the recently reported new functions of cholesterol binding proteins in cholesterol homeostasis, function and trafficking, and explores the molecular mechanisms whereby sterol sensors respond to glucose and other ligands to regulate diverse cellular functions in metabolism. Several new models are proposed from studies on a range of sterol binding proteins including Insig, SCAP, LXR, HMG-CoAR, NPC1 and NPC2. (C) 2009 Elsevier Ireland Ltd. All rights reserved

引用

页码：1 / 6

页数：6

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