Practical aspects of real-time reaction monitoring using multi-nuclear high resolution FlowNMR spectroscopy

被引：72

作者：

Hall, Andrew M. R. ^{[1
]}

Chouler, Jonathan C. ^{[1
]}

Codina, Anna ^{[2
]}

Gierth, Peter T. ^{[2
]}

Lowe, John P. ^{[3
]}

Hintermair, Ulrich ^{[1
]}

机构：

[1] Univ Bath, Ctr Sustainable Chem Technol, Bath BA2 7AY, Avon, England

[2] Bruker UK Ltd, Banner Lane, Coventry CV4 9GH, W Midlands, England

[3] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2016年 / 6卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

RAPID-INJECTION NMR; PERFORMANCE LIQUID-CHROMATOGRAPHY; ONLINE NMR; CHEMICAL-REACTIONS; TUBE NMR; LC-NMR; DESIGN; POLYMERIZATION; SPECTROMETRY; SENSITIVITY;

D O I：

10.1039/c6cy01754a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

FlowNMR spectroscopy is an excellent technique for non-invasive real-time reaction monitoring under relevant conditions that avoids many of the limitations that bedevil other reaction monitoring techniques. With the recent commercial availability of FlowNMR hard-and software solutions for high resolution spectrometers it is enjoying increased popularity in both academia and industry. We present an account on practical aspects of high field multi-nuclear FlowNMR for reaction monitoring including apparatus design, flow effects, acquisition parameters and data treatment, which are important to consider if accurate kinetic data are to be obtained from FlowNMR experiments. Flow effects on NMR peak areas are particularly important as they can lead to large quantification errors if overlooked, but can easily be corrected for and even used to increase temporal resolution with suitably adjusted instrument settings.

引用

页码：8406 / 8417

页数：12