Cytotoxic sterols and saponins from the starfish Certonardoa semiregularis

被引：36
作者：
Wang, WH
Hong, JK
Lee, CO
Im, KS
Choi, JS
Jung, JH [1 ]
机构：
[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea
[2] Inst for Basic Sci, Seoul, South Korea
[3] Korea Res Inst Chem Technol, Pharmaceut Screening Ctr, Taejon 305606, South Korea
[4] Pukyong Natl Univ, Pusan, South Korea
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 04期
关键词：
D O I：
10.1021/np030427u
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eleven new polyhydroxysterols (1-11) and eight new saponins (12-19) were isolated from the brine shrimp active fraction of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis and chemical derivatization. The structural variations of these compounds are due to the hydroxylation pattern of the sterol nucleus, the functionalization of the side chain, or the nature and location of the saccharide moiety. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines.
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页码：584 / 591
页数：8
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