Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae

被引：47

作者：

Novotny, Laura A.

Jurcisek, Joseph A.

Godfroid, Fabrice

Poolman, Jan T.

Denoel, Philippe A.

Bakaletz, Lauren O.

机构：

[1] Ohio State Univ, Dept Pediat, Coll Med & Publ Hlth, Columbus Childrens Res Inst,Ctr Microbial Pathoge, Columbus, OH 43205 USA

[2] GlaxoSmithKline Biol, Bacterial Vaccines Res & Dev, B-1330 Rixensart, Belgium

来源：

VACCINE | 2006年 / 24卷 / 22期

关键词：

superinfection; polymicrobial disease; conjugate vaccine; LPD;

D O I：

10.1016/j.vaccine.2006.03.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred similar to 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4804 / 4811

页数：8