Fast 2D NMR ligand screening using Hadamard spectroscopy

被引：17

作者：

Feliz, Miguel

García, Jesús

Aragón, Eric

Pons, Miquel

机构：

[1] Univ Barcelona, Lab Biomol NMR, Inst Res Biomed, E-08028 Barcelona, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 22期

关键词：

D O I：

10.1021/ja0608949

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fast 2D NMR-based screening can be achieved using Hadamard encoded spectroscopy to focus on the signals of interest (e.g., enzyme active or ligand recognition sites). By recording a set of Hadamard spectra (a -Hadamard constellation-) with relative offsets comparable to the excitation bandwidth, quantitative ligand-induced shifts can be obtained from peak intensities. Copyright © 2006 American Chemical Society.

引用

收藏

页码：7146 / 7147

页数：2

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