Value of Optical Coherence Tomography Angiography Imaging in Diagnosis and Treatment of Hemangioblastomas in von Hippel-Lindau Disease

被引：21

作者：

Lang, Stefan J. ^{[1
]}

Cakir, Bertan ^{[1
]}

Evers, Charlotte ^{[1
]}

Ludwig, Franziska ^{[1
]}

Lange, Clemens A. K. ^{[1
]}

Agostini, Hansjuergen T. ^{[1
]}

机构：

[1] Univ Freiburg, Fac Med, Med Ctr, Ctr Eye, Killianstr 5, D-79106 Freiburg, Germany

来源：

OPHTHALMIC SURGERY LASERS & IMAGING RETINA | 2016年 / 47卷 / 10期

关键词：

AMPLITUDE-DECORRELATION ANGIOGRAPHY; NEOVASCULARIZATION; GROWTH; RETINA;

D O I：

10.3928/23258160-20161004-07

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

BACKGROUND AND OBJECTIVE: The introduction of optical coherence tomography angiography (OCTA) provides new insights into the retinal vasculature. The aim of this study was to explore the value of OCTA in imaging retinal hemangioblastomas and monitoring laser treatment in patients with von Hippel- Lindau (VHL) disease. PATIENTS AND METHODS: Ten eyes of 10 patients with VHL disease were included in this retrospective case series. All patients underwent complete ophthalmological work-up including OCTA for retinal and optic nerve head hemangioblastoma. RESULTS: Two patients showed retinal scars and no recurrence of hemangioblastoma in OCTA. Three patients revealed recurrent hemangioblastomas. Two patients demonstrated a new hemangioblastoma. Three patients showed hemangioblastomas of the optic nerve head. Successful laser photocoagulation could be monitored with OCTA. CONCLUSIONS: Screening for retinal hemangioblastomas with OCTA alone is not possible. OCTA may help to distinguish hemangioblastomas and other lesions in VHL disease, especially after treatment and allows the differentiation from harmless nonvascular lesions in questionable cases.

引用

页码：935 / 946

页数：12

共 23 条

[1]

Binderup MLM, 2013, DAN MED J, V60

[2] Optical Coherence Tomography Angiography during Follow-Up: Qualitative and Quantitative Analysis of Mixed Type I and II Choroidal Neovascularization after Vascular Endothelial Growth Factor Trap Therapy [J].

Coscas, Gabriel ;

Lupidi, Marco ;

Coscas, Florence ;

Francais, Catherine ;

Cagini, Carlo ;

Souied, Eric H. .

OPHTHALMIC RESEARCH, 2015, 54 (02) :57-63

[3] Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system [J].

Gao, Simon S. ;

Liu, Gangjun ;

Huang, David ;

Jia, Yali .

OPTICS LETTERS, 2015, 40 (10) :2305-2308

[4] OUTER RETINA CAPILLARY INVASION AND ELLIPSOID ZONE LOSS IN MACULAR TELANGIECTASIA TYPE 2 IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY [J].

Gaudric, Alain ;

Krivosic, Valerie ;

Tadayoni, Ramin .

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2015, 35 (11) :2300-2306

[5] Vitreoretinal Surgery for Severe Retinal Capillary Hemangiomas in Von Hippel-Lindau Disease [J].

Gaudric, Alain ;

Krivosic, Valerie ;

Duguid, Graham ;

Massin, Pascale ;

Giraud, Sophie ;

Richard, Stephane .

OPHTHALMOLOGY, 2011, 118 (01) :142-149

[6]

GROSSNIKLAUS HE, 1992, OPHTHALMOLOGY, V99, P140

[7]

HAINING WM, 1967, ARCH OPHTHALMOL-CHIC, V78, P475

[8] OPTICAL COHERENCE TOMOGRAPHY [J].

HUANG, D ;

SWANSON, EA ;

LIN, CP ;

SCHUMAN, JS ;

STINSON, WG ;

CHANG, W ;

HEE, MR ;

FLOTTE, T ;

GREGORY, K ;

PULIAFITO, CA ;

FUJIMOTO, JG .

SCIENCE, 1991, 254 (5035) :1178-1181

[9] Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye [J].

Jia, Yali ;

Bailey, Steven T. ;

Hwang, Thomas S. ;

McClintic, Scott M. ;

Gao, Simon S. ;

Pennesi, Mark E. ;

Flaxel, Christina J. ;

Lauer, Andreas K. ;

Wilson, David J. ;

Hornegger, Joachim ;

Fujimoto, James G. ;

Huang, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (18) :E2395-E2402

[10] Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma [J].

Jia, Yali ;

Wei, Eric ;

Wang, Xiaogang ;

Zhang, Xinbo ;

Morrison, John C. ;

Parikh, Mansi ;

Lombardi, Lori H. ;

Gattey, Devin M. ;

Armour, Rebecca L. ;

Edmunds, Beth ;

Kraus, Martin F. ;

Fujimoto, James G. ;

Huang, David .

OPHTHALMOLOGY, 2014, 121 (07) :1322-1332

← 1 2 3 →