Novel fluorescent probe for the selective detection of organophosphorous nerve agents through a cascade reaction from oxime to nitrile via isoxazole

被引：44
作者：
Lee, Heejin [1 ]
Kim, Hae-Jo [1 ]
机构：
[1] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, South Korea
来源：
TETRAHEDRON | 2014年 / 70卷 / 18期
关键词：
Chemodosimeter; Fluorescence; Nerve agents; Organophosphorous; SENSORS;
D O I：
10.1016/j.tet.2014.03.026
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel fluorescent probe based on fluoresceinyloxime was developed for detection of such organophosphorous compounds as nerve agents. The probe underwent an abnormal cascade reaction from oxime to nitrile via isoxazole in aqueous solvent and displayed a highly selective fluorescence response to diethylchlorophosphate (DCP) with the detection limit of 10 nM DCP in HEPES buffer. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2966 / 2970
页数：5
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